Gene signature of the post-Chernobyl papillary thyroid cancer

European Journal of Nuclear Medicine and Molecular Imaging
D Handkiewicz-JunakBarbara Jarzab

Abstract

Following the nuclear accidents in Chernobyl and later in Fukushima, the nuclear community has been faced with important issues concerning how to search for and diagnose biological consequences of low-dose internal radiation contamination. Although after the Chernobyl accident an increase in childhood papillary thyroid cancer (PTC) was observed, it is still not clear whether the molecular biology of PTCs associated with low-dose radiation exposure differs from that of sporadic PTC. We investigated tissue samples from 65 children/young adults with PTC using DNA microarray (Affymetrix, Human Genome U133 2.0 Plus) with the aim of identifying molecular differences between radiation-induced (exposed to Chernobyl radiation, ECR) and sporadic PTC. All participants were resident in the same region so that confounding factors related to genetics or environment were minimized. There were small but significant differences in the gene expression profiles between ECR and non-ECR PTC (global test, p < 0.01), with 300 differently expressed probe sets (p < 0.001) corresponding to 239 genes. Multifactorial analysis of variance showed that besides radiation exposure history, the BRAF mutation exhibited independent effects on the PTC expression p...Continue Reading

References

Sep 3, 1992·Nature·V S KazakovL N Astakhova
Sep 3, 1992·Nature·K BaverstockD Williams
Dec 26, 2001·Nucleic Acids Research·Ron EdgarAlex E Lash
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·Jorge LimaManuel Sobrinho-Simões
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·Kristian UngerGerry Thomas
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·Atsushi KumagaiShunichi Yamashita
Apr 7, 2005·British Journal of Cancer·V DetoursC Maenhaut
May 19, 2005·Journal of the National Cancer Institute·Elisabeth CardisDillwyn Williams
Sep 30, 2006·Cellular Signalling·Changyue GuoJames M Larner
Dec 2, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Dillwyn Williams
Sep 4, 2009·Thyroid : Official Journal of the American Thyroid Association·Leighton SteinLesleyann Hawthorn
Sep 9, 2009·International Journal of Radiation Oncology, Biology, Physics·Steven EschrichJavier F Torres-Roca
Nov 11, 2010·Radiation and Environmental Biophysics·M FuzikS Yamashita
Feb 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·Eloïse DrayPatrick Sung
Feb 18, 2011·Clinical Oncology : a Journal of the Royal College of Radiologists·R M TuttleM D Tronko
Mar 18, 2011·Clinical Oncology : a Journal of the Royal College of Radiologists·C MaenhautB Jarzab
Dec 14, 2011·Thyroid : Official Journal of the American Thyroid Association·Geneviève SassolasAlfredo Fusco
May 10, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Britta LangenEva Forssell-Aronsson
Jun 20, 2013·Endocrine Connections·Susana PastorAntonia Velázquez
Oct 19, 2013·The Journal of Clinical Investigation·Julio C Ricarte-FilhoJames A Fagin
Nov 25, 2014·Cell·UNKNOWN Cancer Genome Atlas Research Network
Dec 17, 2014·Nuclear Medicine and Biology·Nils RudqvistEva Forssell-Aronsson

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Citations

Sep 29, 2017·Thyroid : Official Journal of the American Thyroid Association·Shunichi YamashitaVladimir Saenko
Jun 23, 2016·Archives of Toxicology·Aleksandra FucicElizaveta Neronova
Oct 9, 2018·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Xueying GohChwee Ming Lim
Nov 9, 2019·The Journal of Clinical Endocrinology and Metabolism·Aglaia KyrilliBernard Corvilain
Feb 9, 2018·Oncotarget·Dumitru A IacobasRaj K Tiwari
Aug 31, 2018·Radiation Protection Dosimetry·Geraldine Thomas
Sep 5, 2019·Cancers·Keiji SuzukiNorisato Mitsutake
Oct 24, 2020·Journal of Cellular and Molecular Medicine·Lizhi LinYizuo Chen
Dec 15, 2020·Journal of Cellular and Molecular Medicine·Hongyu ZhaoWentao Yue
Nov 18, 2020·Journal of Experimental & Clinical Cancer Research : CR·Carla ColomboMaria Grazia Borrello
Apr 19, 2020·Computational Biology and Chemistry·Yong-Ying QinXiao-Zhun Tang
Jul 3, 2021·Cancers·Yuchen JinWeijun Wei
Nov 7, 2020·Indian Journal of Pathology & Microbiology·Sang Ah LeeYoung Hee Maeng

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Datasets Mentioned

BETA
GSE35570

Methods Mentioned

BETA
PCA

Software Mentioned

BRB
ArrayTools
Panther
Panther pathway

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