PMID: 11913788Mar 27, 2002Paper

Gene structure and alternative splicing of murine podocalyxin: a member of the CD34 sialomucin family

DNA Sequence : the Journal of DNA Sequencing and Mapping
J LiD B Kershawt

Abstract

Podocalyxin is a sialoglycoprotein of the glomerular podocytes, vascular endothelial cells, platelets, and hemopoietic stem cells. The function of podocalyxin is unknown, but it contains most of the protein bound sialic acid in the glomerulus and is considered vital in the structure and function of the glomerular filtration apparatus. The murine podocalyxin full-length cDNA has been determined and is 5,318 base pairs. The gene localizes to chromosome 6B1 by FISH analysis and contains eight major exons with one additional alternatively spliced exon. The alternatively spliced isoform of podocalyxin codes for a truncated intracellular domain and is expressed in a tissue specific pattern in parallel with full-length podocalyxin. The organization of the gene structure of murine podocalyxin is similar to the murine CD34 gene and suggests a distant evolutionary relationship to CD34.

References

Nov 5, 1997·Kidney International·C SegawaH Yokoyama
Mar 18, 1999·The American Journal of Pathology·A MiettinenH Holthöfer
May 26, 1999·FEMS Microbiology Letters·T A Tatusova, T L Madden
Mar 18, 2000·The Journal of Biological Chemistry·C SassettiS D Rosen

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Citations

Mar 11, 2004·British Journal of Haematology·Laura KerosuoAaro Miettinen
Jan 22, 2005·Gene Expression Patterns : GEP·Nathalia VitureiraFerran Burgaya
Feb 11, 2012·The American Journal of Pathology·Sravan KakaniMarjan Huizing
Sep 26, 2020·Frontiers in Cell and Developmental Biology·Amanda J EakinCristina M Branco
Nov 7, 2008·Journal of Cell Science·Julie S Nielsen, Kelly M McNagny

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