Aug 7, 2010

Gene targeting and expression modulation by peptide nucleic acids (PNA)

Current Pharmaceutical Design
Peter E Nielsen

Abstract

Peptide nucleic acids (PNA) are artificial structural mimics of nucleic acids capable of sequence specific hybridization to both RNA and DNA. Thus they have obvious potential as gene targeting agents for drug discovery approaches. An overview with emphasis on recent progress on RNA "interference" (antisense), targeting of duplex DNA and gene targeted repair and transcription interference using PNA, as well as on PNA delivery and potential PNA anti-infectives is given.

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Mentioned in this Paper

Peptide Nucleic Acids
Drug Delivery Systems
Nucleic Acid Hybridization Procedure
Antisense RNA
Mimic brand of tebufenozide
Nucleic Acids
Microbicides
Anti-Infective Agents
Metazoa
Crossbreeding

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