Gene targeting and the biology of learning and memory

Annual Review of Genetics
A J SilvaK P Giese

Abstract

The general goal of genetic studies of learning and memory is to develop and test theories that explain the animal's behavior in neuroanatomical, neurophysiological, cellular, and molecular terms. In this review we describe the role that gene targeting and other transgenic techniques have had in the study of mammalian learning and memory. We focus especially on the hippocampus, a brain structure that is thought to be central to the processing and temporary storage of complex information. We also discuss the main issues that confront this young field, as well as our vision for its future.

References

Jun 1, 1975·Behavioral Biology·W A Little, G L Shaw
Apr 1, 1976·Experimental Neurology·J O'Keefe
May 1, 1992·Science·J J Kim, M S Fanselow
Apr 1, 1992·Current Opinion in Neurobiology·S E PetersenM Corbetta
Jan 1, 1989·Progress in Neurobiology·H Matthies
Jan 1, 1989·Annual Review of Neuroscience·M Ito
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·D MetzgerP Chambon
Sep 8, 1995·Science·R KühnK Rajewsky
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·Z L WuD R Storm
Aug 1, 1994·Current Biology : CB·C F StevensY Wang
Aug 1, 1994·Current Biology : CB·C F Stevens, I Verma
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·O HvalbyP Andersen
Sep 23, 1993·Biochimica Et Biophysica Acta·K A Lee, N Masson
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Jan 1, 1993·Annual Review of Psychology·L R SquireG Musen

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Citations

Aug 2, 2001·Journal of Neuroscience Methods·T Wells, D A Carter
Mar 24, 1999·Trends in Neurosciences·P C OrbanR Brambilla
Oct 30, 2001·Behavioural Brain Research·F J van der Staay, T Steckler
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M H BassantJ M Billard
Aug 29, 2002·Nature·Alcino J Silva, Sheena A Josselyn
Feb 28, 2002·The European Journal of Neuroscience·P WeberP Chambon
May 7, 2002·Learning & Memory·Angelo ContarinoLisa H Gold
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Jürgen Wess
Mar 13, 1999·Annual Review of Psychology·E A CapaldiS E Fahrback
Jun 10, 2005·Experimental Physiology·Mark PickeringJohn J O'Connor
Oct 19, 2005·Neurobiology of Learning and Memory·Craig M Powell
Sep 4, 2007·Progress in Brain Research·Mark Pickering, John J O'Connor
Jun 4, 2002·Nature Reviews. Neuroscience·Jeansok J Kim, David M Diamond
Nov 20, 2001·Nature Neuroscience·M OhnoA J Silva
Dec 1, 2007·International Journal of Older People Nursing·Bronagh WalshJane Hopkinson
May 1, 2011·Wiley Interdisciplinary Reviews. Cognitive Science·Susanna Pietropaolo, Wim E Crusio

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Methods Mentioned

BETA
transgenic
transgenics
imaging techniques

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