Gene therapy: a battle against biological barriers

Current Molecular Medicine
Y Kaneda

Abstract

One factor critical to successful human gene therapy is development of efficient gene delivery systems. Although numerous vector systems for gene transfer have been developed, a perfect vector system has not yet been constructed. Difficulties of in vivo gene transfer appear to result from resistance of living cells to invasion by foreign materials and from interference of cellular functions. We should analyze what barriers in tissues affect in vivo gene transfection and how to solve these problems for gene therapy. In this review article, the biological barriers to in vivo gene transfection are discussed and possible solutions to each barrier are discussed with respect to construction of a perfect gene therapy vector system.

Citations

Dec 3, 2014·Neuropharmacology·A J KwilaszL R Watkins
Apr 8, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·C SardoG Cavallaro
Nov 8, 2003·World Journal of Gastroenterology : WJG·Chao Zhang, Zhan-Kui Liu
Sep 20, 2017·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Erhan Süleymanoğlu
Jul 8, 2020·International Journal of Molecular Sciences·Elżbieta Pędziwiatr-WerbickaMaria Bryszewska
Mar 31, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rossella FarraBarbara Dapas
Mar 8, 2017·Expert Opinion on Drug Delivery·Lucia ScarabelBarbara Dapas
Jan 23, 2021·The Journal of Physical Chemistry. B·Elżbieta Pędziwiatr-WerbickaMaria Bryszewska
Jun 22, 2006·Journal of the American Chemical Society·Sathya SrinivasachariTheresa M Reineke
Aug 21, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Lisa E PrevetteMatthew L Lynch
Jul 25, 2021·International Journal of Molecular Sciences·Myriam Sainz-RamosJose Luis Pedraz
Aug 19, 2007·Journal of Medicinal Chemistry·Haigang ChenXin Guo
Mar 3, 2005·Journal of the American Chemical Society·Yemin Liu, Theresa M Reineke

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