Gene therapy approaches against cancer using in vivo and ex vivo gene transfer of interleukin-12

Immunotherapy
R Hernandez-AlcocebaC Smerdou

Abstract

IL-12 is an immunostimulatory cytokine with strong antitumor properties. Systemic administration of IL-12 in cancer patients led to severe toxic effects, prompting the development of gene therapy vectors able to express this cytokine locally in tumors. Both nonviral and viral vectors have demonstrated a high antitumor efficacy in preclinical tumor models. Some of these vectors, including DNA electroporation, adenovirus and ex vivo transduced dendritic cells, were tested in patients, showing low toxicity and moderate antitumor efficacy. IL-12 activity can be potentiated by molecules with immunostimulatory, antiangiogenic or cytotoxic activity. These combination therapies are of clinical interest because they could lower the threshold for IL-12 efficacy, increasing the therapeutic potential of gene therapy and preventing the toxicity mediated by this cytokine.

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Mar 23, 2017·The Journal of Biological Chemistry·Susanne ReitbergerMatthias J Feige
Jan 16, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yu-Qing XieLi Tang
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Jul 8, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Reza MohammadinejadAli Zarrabi

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Methods Mentioned

BETA
transfection
genetic modifications

Clinical Trials Mentioned

NCT01703754
NCT01397708

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