PMID: 11605184Oct 18, 2001Paper

Gene therapy approaches for the management of non-small cell lung cancer

Seminars in Oncology
J A RothR E Meyn

Abstract

Targeting the specific genetic lesions responsible for carcinogenesis and cancer progression is an attractive strategy for developing more effective anticancer therapies and reducing treatment-related toxicity. The restoration of defective tumor suppressor gene pathways by replacement of tumor suppressor genes in cancer cells has been studied in lung cancer. The most extensively studied agent is the wild-type p53 tumor suppressor gene delivered by an adenoviral vector. Clinical trials to date in non-small cell lung cancer and head and neck cancer have consistently shown evidence of gene transduction and expression, mediation of apoptosis, and clinical responses including pathologic complete responses. However, it also is clear that this approach can be improved. Promising avenues for investigation include improved gene delivery systems, induction of bystander effects, and adjuvant use of gene therapy with conventional chemotherapy, radiation therapy, and surgery. However, these strategies will need further refinement to succeed clinically. This review examines several important issues in cancer gene therapy in general and the most recent achievements in gene therapy for non-small cell lung cancer.

Citations

Jun 28, 2003·The Journal of Thoracic and Cardiovascular Surgery·Peter K M KimTimothy R Billiar
Nov 27, 2002·Surgical Oncology·Tien HoangJoan H Schiller
Jan 24, 2007·Thoracic Surgery Clinics·Eric M Toloza
Jan 25, 2017·Omega·P VijayalakshmiB M Suresh
Jun 13, 2006·Journal of Cellular Biochemistry·Eric M TolozaH Kim Lyerly
Jan 7, 2004·Clinical Lung Cancer·Eelco FokkemaElisabeth G E de Vries

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