PMID: 11338380May 8, 2001Paper

Gene therapy: current status and promise

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Y Kaneda

Abstract

As of summer 2000, more than 400 protocols developed for human gene therapy have been reported, and there have been recent successful applications in some diseases such as arteriosclerosis obliterance, immunodeficiency X-1 (SCID-X1) and hemophilia B. However, complications have also occurred. Successful gene therapy is dependent on the development of an effective gene delivery system. One approach is development of chimeric vector systems that combine at least two different vector systems. However, a perfect vector system has not yet been constructed. Difficulties of in vivo gene transfer appear to result from resistance of living cells to invasion by foreign materials and from interference of cellular functions. We should reevaluate what barriers in tissues affect in vivo gene transfection and how to solve these problems for gene therapy. Moreover, in Japan, there should be more extensive preparation of social systems to promote clinical trials based on basic research.

References

Mar 23, 1990·Science·J A WolffP L Felgner
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P L FelgnerM Danielsen
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·H E von der LeyenV J Dzau
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·R MorishitaV J Dzau
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·M J MannV J Dzau
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·J S RemyJ P Behr
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R MorishitaV J Dzau
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G J NabelA E Chang
Mar 27, 1996·Biochemical and Biophysical Research Communications·S HayashiT Ogihara
Jan 1, 1995·Molecular and Cell Biology of Human Diseases Series·A FassatiG Dickson
May 19, 1998·Nature Medicine·D M Pardoll
Jun 23, 1999·Molecular Medicine Today·Y KanedaR Morishita
Apr 28, 2000·Science·M Cavazzana-CalvoA Fischer
Nov 14, 2000·Molecular Medicine Today·P E Monahan, R J Samulski

❮ Previous
Next ❯

Citations

Jul 2, 2002·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Tsukasa Okiyoneda, Hirofumi Kai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Current Opinion in Oncology
A Weyerbrock, E H Oldfield
American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice
Roland W Herzog, J N Hagstrom
Expert Opinion on Biological Therapy
H Bobby Gaspar, Adrian J Thrasher
© 2021 Meta ULC. All rights reserved