Gene therapy development in hearing research in China.

Gene Therapy
Zhen ZhangFeng Liu

Abstract

Sensorineural hearing loss, the most common form of hearing impairment, is mainly attributable to genetic mutations or acquired factors, such as aging, noise exposure, and ototoxic drugs. In the field of gene therapy, advances in genetic and physiological studies and profound increases in knowledge regarding the underlying mechanisms have yielded great progress in terms of restoring the auditory function in animal models of deafness. Nonetheless, many challenges associated with the translation from basic research to clinical therapies remain to be overcome before a total restoration of auditory function can be expected. In recent years, Chinese research teams have promoted various developmental efforts in this field, including gene sequencing to identify additional potential loci that cause deafness, studies to elucidate the underlying molecular mechanisms, and research to optimize vectors and delivery routes. In this review, we summarize the state of the field and focus mainly on the progress of gene therapy in animal model studies and the optimization of therapeutic strategies in China.

References

Nov 1, 1984·American Journal of Otolaryngology·J P Harris, A F Ryan
Dec 9, 1997·Neuron·A J Hudspeth
Mar 21, 1998·Nature Genetics·X C LiE R Wilcox
Mar 21, 1998·Nature Genetics·A WatanabeM Tachibana
Apr 29, 1998·The Journal of Cell Biology·H D GabrielK Willecke
Feb 19, 2002·Nature Genetics·Sarah VreugdeKaren P Steel
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tom WalshKaren B Avraham
Oct 24, 2002·Human Molecular Genetics·Linda M PetersRobert J Morell
Oct 31, 2002·Development·C-M Amy Chen, Constance L Cepko
Feb 25, 2003·The Journal of the Acoustical Society of America·Peggy B NelsonDavid A Nelson
Apr 11, 2003·American Journal of Human Genetics·Zubair M AhmedEdward R Wilcox
Aug 21, 2004·Development·Kate F Barald, Matthew W Kelley
Mar 9, 2005·Lancet·Richard J H SmithKarl R White
Jul 11, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zhijian WuR Jude Samulski
Nov 4, 2006·Hearing Research·Mark PraetoriusHinrich Staecker
Aug 3, 2007·American Journal of Physiology. Cell Physiology·Florian LangPhiline Wangemann
Jan 9, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yuhe LiuKeiya Ozawa
Mar 22, 2008·Journal of Neurotrauma·Norihiko MuraiMats Ulfendahl
May 13, 2009·Biochemical and Biophysical Research Communications·Yunfeng WangXi Lin
Aug 4, 2009·American Journal of Human Genetics·Saima RiazuddinChristoph Fahlke
Nov 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·A Eliot ShearerRichard J H Smith
Jan 16, 2013·Developmental Biology·Elizabeth Carroll DriverMatthew W Kelley
Jan 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Denise YanXue Z Liu

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Citations

Jul 31, 2020·Gene Therapy·Qiurong Ding

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Methods Mentioned

BETA
cochlear implants
transfection
cochlear implant

Clinical Trials Mentioned

ISRCTN59733689
NCT02132130
NCT03996824
NCT03300687

Software Mentioned

OTO

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