PMID: 16518057Mar 7, 2006Paper

Gene therapy for breast cancer. --Review of clinical gene therapy trials for breast cancer and MDR1 gene therapy trial in Cancer Institute Hospital

Breast Cancer : the Journal of the Japanese Breast Cancer Society
Shunji TakahashiYoshikazu Sugimoto

Abstract

Gene therapy for advanced breast cancer is anticipated to be a useful therapeutic approach. Strategies in ongoing clinical protocols can be divided into four groups: (1) suppression of oncogenes or transfer of tumor-suppressor genes; (2) enhancement of immunological response; (3) transfer of suicide genes; (4) protection of bone marrow using drug resistance genes. We have started a clinical study of multidrug resistance (MDR1) gene therapy. Advanced breast cancer patients received high dose chemotherapy and autologous peripheral blood stem cell transplantation(PBSCT)with MDR1-transduced hematopoietic cells, and then were treated with docetaxel. Two patients have been treated so far, and in vivo enrichment of MDR1-transduced cells with docetaxel treatment has been seen. Both patients are in complete remission and had no apparent adverse effects from the MDR1 gene transfer.

References

Feb 20, 1992·International Journal of Cancer. Journal International Du Cancer·A M ThompsonC M Steel
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C HesdorfferK Antman
Oct 1, 1998·The New England Journal of Medicine·G N Hortobagyi
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H S PandhaN R Lemoine
Jul 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G N HortobagyiM C Hung
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Donald A BerryMary M Horowitz
Apr 19, 2002·The New England Journal of Medicine·Salima Hacein-Bey-AbinaMarina Cavazzana-Calvo
Jul 26, 2002·Seminars in Oncology·Teresa M FoyMartin A Cheever
Sep 17, 2003·Journal of Biomedicine & Biotechnology·Susy SchollDavid Miles
Jan 17, 2004·Science·Utpal P DavéNeal G Copeland
Feb 27, 2004·The New England Journal of Medicine·Matthew P McCormack, Terence H Rabbitts
Apr 16, 2004·The New England Journal of Medicine·Anton Berns
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeremy P BraybrookeAdrian L Harris

❮ Previous
Next ❯

Citations

Jan 5, 2010·Journal of Experimental & Clinical Cancer Research : CR·ZhenZhen ZhaoXianQing Jin
Feb 2, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Miriam ColomboPaolo Verderio
Dec 23, 2014·Molecular Pharmaceutics·Guimei LinLeaf Huang
May 12, 2009·Advanced Drug Delivery Reviews·Minhyung Lee
Aug 5, 2006·The Lancet Oncology·Maksym V YezhelyevRuth M O'Regan
Jun 28, 2007·Expert Opinion on Investigational Drugs·Paolo CarliniGianluigi Ferretti
May 18, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Jin Kyung BaeYoung Hee Choi
Nov 21, 2007·Breast Cancer Research and Treatment·Matthew Ellis, Cynthia Ma
Jan 30, 2019·Annual Review of Medicine·Barry S Coller
Nov 21, 2015·Cancer Gene Therapy·S R HusainR K Puri
Sep 14, 2010·Acta Oncologica·Niels BasslerJørgen B Petersen
Feb 23, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Marinella Messina, Bruce G Robinson
Mar 24, 2012·Immunologic Research·Gordana KonjevicIvan Spuzic
Jun 14, 2014·Journal of Physical Therapy Science·Flávia Nascimento de CarvalhoRosalina Jorge Koifman
Nov 28, 2020·International Journal of Nanomedicine·Chenglong WangGuoxiong Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Shunji Takahashi, Yoshikazu Sugimoto
Nihon rinsho. Japanese journal of clinical medicine
Shunji Takahashi, Yoshikazu Sugimoto
Gan to kagaku ryoho. Cancer & chemotherapy
Shunji TakahashiYoshikazu Sugimoto
© 2021 Meta ULC. All rights reserved