Gene therapy for diabetes mellitus

Current Molecular Medicine
T Yamaoka

Abstract

There are diverse strategies for gene therapy of diabetes mellitus. Prevention of beta-cell autoimmunity is a specific gene therapy for prevention of type 1 (insulin-dependent) diabetes in a preclinical stage, whereas improvement in insulin sensitivity of peripheral tissues is a specific gene therapy for type 2 (non-insulin-dependent) diabetes. Suppression of beta-cell apoptosis, recovery from insulin deficiency, and relief of diabetic complications are common therapeutic approaches to both types of diabetes. Several approaches to insulin replacement by gene therapy are currently employed: 1) stimulation of beta-cell growth, 2) induction of beta-cell differentiation and regeneration, 3) genetic engineering of non-beta cells to produce insulin, and 4) transplantation of engineered islets or beta cells. In type 1 diabetes, the therapeutic effect of beta-cell proliferation and regeneration is limited as long as the autoimmune destruction of beta cells continues. Therefore, the utilization of engineered non-beta cells free from autoimmunity and islet transplantation with immunological barriers are considered potential therapies for type 1 diabetes. Proliferation of the patients' own beta cells and differentiation of the patients' o...Continue Reading

Citations

May 12, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Han Chang KangYou Han Bae
Sep 5, 2002·Biochemical and Biophysical Research Communications·Takashi Yamaoka
Oct 1, 2008·Clinical & Developmental Immunology·Peter Klein Klouwenberg, Louis Bont
May 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shuyuan ChenPaul A Grayburn
Jul 30, 2010·Expert Opinion on Pharmacotherapy·Alberto VerrottiFrancesco Chiarelli
Jun 2, 2007·Journal of Drug Targeting·A A PalizbanH Galehdari
Jun 5, 2003·Expert Opinion on Biological Therapy·Takashi Yamaoka
Apr 2, 2013·Journal of Bioscience and Bioengineering·Vahid JajarmiBahram Kazemi
Jan 26, 2008·Journal of Magnetic Resonance Imaging : JMRI·Aravind Arepally
Nov 8, 2003·World Journal of Gastroenterology : WJG·Chao Zhang, Zhan-Kui Liu

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