Gene Therapy for Human Sensorineural Hearing Loss

Frontiers in Cellular Neuroscience
Yin RenKonstantina M Stankovic

Abstract

Hearing loss is the most common sensory impairment in humans and currently disables 466 million people across the world. Congenital deafness affects at least 1 in 500 newborns, and over 50% are hereditary in nature. To date, existing pharmacologic therapies for genetic and acquired etiologies of deafness are severely limited. With the advent of modern sequencing technologies, there is a vast compendium of growing genetic alterations that underlie human hearing loss, which can be targeted by therapeutics such as gene therapy. Recently, there has been tremendous progress in the development of gene therapy vectors to treat sensorineural hearing loss (SNHL) in animal models in vivo. Nevertheless, significant hurdles remain before such technologies can be translated toward clinical use. These include addressing the blood-labyrinth barrier, engineering more specific and effective delivery vehicles, improving surgical access, and validating novel targets. In this review, we both highlight recent progress and outline challenges associated with in vivo gene therapy for human SNHL.

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Citations

Aug 17, 2020·Current Opinion in Otolaryngology & Head and Neck Surgery·Farzad Forouzandeh, David A Borkholder
Dec 5, 2019·Biomedical Optics Express·Marilisa RomitoDemetri Psaltis
Apr 28, 2020·Human Molecular Genetics·Karina LezirovitzJeanne Oiticica
May 20, 2020·Gene Therapy·Yiyang LanGuisheng Zhong
May 11, 2020·Advanced Drug Delivery Reviews·Ning DingXue Gao
Feb 9, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Camille LevieVincent Van Rompaey
Feb 20, 2021·Neuro-oncology Advances·Yin RenKonstantina M Stankovic
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Jun 3, 2021·Nanomaterials·Dan Cristian GheorgheAlexandru Mihai Grumezescu
Mar 23, 2020·Hearing Research·Gwenaelle G S Géléoc, Aziz El-Amraoui

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Methods Mentioned

BETA
pharmacotherapies
cochlear implant
transgenic
scanning electron microscopy
transfection
dissection
fluorescence imaging
light sheet

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