PMID: 11901916Mar 21, 2002Paper

Gene therapy for lung neoplasms

Clinics in Chest Medicine
S M AlbeldaD H Sterman

Abstract

The field of gene therapy is still in its infancy, but significant accomplishments have been achieved. The ability to transfer genes safely and successfully into animals and patients clearly has been established. It is highly likely that in the near future, gene therapy will be shown to have clear therapeutic efficacy in diseases such as the treatment of hemophilia (using adeno-associated virus vectors) and the stimulation of angiogenesis in peripheral vascular disease and myocardial ischemia. Although only Phase 1 cancer gene therapy trials for thoracic malignancy have been conducted (usually in patients with large tumor burdens and at submaximal doses), there are some hints of efficacy at higher doses of vector in trials for localized malignancy. The studies reviewed in this article demonstrate the first attempts to use gene therapy vectors for lung cancer and mesothelioma. Although none of the diseases studied was "cured," valuable lessons have been learned from these trials, especially in defining the challenges of relatively inefficient and transient delivery of transgene in vivo. Using this knowledge, the second phase of gene therapy research has begun, with a strong focus on developing improved vector technology. Given t...Continue Reading

References

Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·S H ChenS L Woo
Jun 1, 1994·The Annals of Thoracic Surgery·W R SmytheS M Albelda
Jan 1, 1996·American Journal of Respiratory Cell and Molecular Biology·D T CurielS M Albelda
Dec 18, 1996·Journal of the National Cancer Institute·T TurszT Le Chevalier
Jan 4, 1997·Lancet·S M FreemanA J Marrogi
Jul 16, 1997·Journal of the National Cancer Institute·A ZieglerU Zangemeister-Wittke
Aug 7, 1997·International Journal of Cancer. Journal International Du Cancer·P CasaliniS Segal
Jun 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I M PopeA R Kinsella
Mar 5, 1998·Journal of the National Cancer Institute·H L Kong, R G Crystal
Apr 29, 1998·Current Opinion in Oncology·J A Roth
Jun 4, 1998·Journal of Immunotherapy·B W RobinsonB Scott
Jul 31, 1998·Hematology/oncology Clinics of North America·N A Wivel, J M Wilson
May 18, 1999·Journal of the National Cancer Institute·S G SwisherM K Waugh
Aug 17, 1999·Current Opinion in Immunology·W S WoldA E Tollefson
Sep 1, 1999·The Journal of Pharmacy and Pharmacology·C R Dass, M A Burton
Dec 2, 1999·Radiation Oncology Investigations·S J ChmuraR R Weichselbaum
Feb 19, 2000·Gene Therapy·P E Monahan, R J Samulski
Apr 5, 2000·The Journal of Clinical Investigation·D H Kirn
Apr 5, 2000·The Journal of Clinical Investigation·C Heise, D H Kirn
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·W N RomK M Tchou-Wong
Aug 10, 2000·Molecular Therapy : the Journal of the American Society of Gene Therapy·G Dranoff
Aug 15, 2000·Annual Review of Biophysics and Biomolecular Structure·S Chesnoy, L Huang
Mar 22, 2001·Journal of the National Cancer Institute·O GautschiU Zangemeister-Wittke
Mar 29, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·R RameshJ A Roth

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Citations

Jul 18, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kristen M Hege, David P Carbone
Jan 28, 2006·Cancer Gene Therapy·R G van der MostD J Nelson
Jul 11, 2006·Respiration; International Review of Thoracic Diseases·Jean-Michel VignaudYves Martinet
Nov 4, 2004·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Vladimír Janout, Gabriela Janoutová
Jun 4, 2004·Expert Opinion on Investigational Drugs·Nabil Saba, Fadlo Khuri

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