PMID: 11901469Mar 20, 2002Paper

Gene therapy for rheumatoid arthritis

Hand Surgery : an International Journal Devoted to Hand and Upper Limb Surgery and Related Research : Journal of the Asia-Pacific Federation of Societies for Surgery of the Hand
J N GouzeJ H Herndon

Abstract

Advances in understanding the biology of rheumatoid arthritis (RA) have opened new therapeutic avenues. One of these, gene therapy, involves the delivery to patients of genes encoding anti-arthritic proteins. This approach has shown efficacy in animal models of RA, and the first human, phase I trial has just been successfully completed. Hand surgery featured prominently in this pioneering study, as a potentially anti-arthritic gene encoding the interleukin-1 receptor antagonist was transferred to the metacarpophalangeal joints of subjects with RA one week before total joint arthroplasty. This study has confirmed that it is possible to transfer genes safely to human joints. It should pave the way for additional application of gene therapy to arthritis and other orthopaedic conditions.

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Citations

Dec 1, 2009·Tissue Engineering. Part B, Reviews·Kyle D AllenLori A Setton
Sep 24, 2020·Journal of Leukocyte Biology·Yan LiuSong Guo Zheng
Apr 2, 2005·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Andreas DietzeK Berg
Oct 24, 2014·Radiology·Mingqian Huang, Mark E Schweitzer
Aug 13, 2008·Expert Opinion on Biological Therapy·Ke-Rong DaiJulio C Fernandes

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