Gene Therapy in Cancer Treatment: Why Go Nano?

Pharmaceutics
Catarina Roma-RodriguesAlexandra R Fernandes

Abstract

The proposal of gene therapy to tackle cancer development has been instrumental for the development of novel approaches and strategies to fight this disease, but the efficacy of the proposed strategies has still fallen short of delivering the full potential of gene therapy in the clinic. Despite the plethora of gene modulation approaches, e.g., gene silencing, antisense therapy, RNA interference, gene and genome editing, finding a way to efficiently deliver these effectors to the desired cell and tissue has been a challenge. Nanomedicine has put forward several innovative platforms to overcome this obstacle. Most of these platforms rely on the application of nanoscale structures, with particular focus on nanoparticles. Herein, we review the current trends on the use of nanoparticles designed for cancer gene therapy, including inorganic, organic, or biological (e.g., exosomes) variants, in clinical development and their progress towards clinical applications.

References

Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P Garin-ChesaW J Rettig
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A K FieldR L Tolman
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Jung ChangLih-Hwa Hwang
Aug 9, 2008·International Journal of Nanomedicine·Stuart C McBainJon Dobson
Nov 11, 2008·International Journal of Nanomedicine·Xiang-Hong PengDong M Shin
Apr 1, 2009·Nano Letters·Asmaa ElbakryMiriam Breunig
Jan 11, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Gajadhar BhaktaAmarnath Maitra
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Apr 8, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin A Cheever, Celestia S Higano
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Khuloud T Al-JamalTommaso Pizzorusso
Aug 17, 2011·Combinatorial Chemistry & High Throughput Screening·Sutapa BaruaKaushal Rege
Nov 19, 2011·Biochemical and Biophysical Research Communications·Sang-Mi RyouKangseok Lee
Jan 25, 2013·International Journal of Molecular Sciences·Sachiko Kaihara Nitta, Keiji Numata
Jul 12, 2013·BioMed Research International·Jong-Min LeeYoung-Seok Cho
Oct 24, 2013·Nature Materials·Vikash P Chauhan, Rakesh K Jain
Nov 5, 2013·Advanced Drug Delivery Reviews·Katie Bates, Kostas Kostarelos
Dec 3, 2013·Journal of Genetic Syndromes & Gene Therapy·Paul ZarogoulidisMarek Malecki
Feb 28, 2014·BioMed Research International·Carrie A FranzenGopal N Gupta
May 6, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joseph W Nichols, You Han Bae
Jun 18, 2014·Nanoscale Research Letters·Solmaz Maleki DizajAhmad Yari Khosroushahi
Jun 26, 2014·BioMed Research International·Catarina Roma-RodriguesPedro Viana Baptista
Sep 18, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Hadis DaraeeAbolfazl Akbarzadeh
Nov 19, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Beate SchultheisJoachim Drevs
Apr 4, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Seyed Mohammad Ali Hosseini RadEhsan Arefian
Jan 1, 2014·Molecular and Cellular Therapies·Magid H Amer
Jun 11, 2015·Journal of Functional Biomaterials·Yuhong WangRaju V S Rajala
Jun 18, 2015·Nanotechnology Reviews·William H Gmeiner, Supratim Ghosh
Jul 26, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haijuan ZouMin Feng
Sep 16, 2015·Molecular Therapy. Nucleic Acids·Jenny K W LamSusan W S Leung
Sep 24, 2015·Journal of Drug Targeting·You-Kyoung KimHu-Lin Jiang
Nov 21, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Myung Soo KimElena V Batrakova

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Citations

Jul 3, 2020·Drug Delivery·Jingjing SongWei Zhang
Aug 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela FerreiraPedro V Baptista
Jan 1, 2021·Frontiers in Oncology·Mariela Montaño-SamaniegoMiguel Ibáñez-Hernández
Feb 9, 2021·International Journal of Pharmaceutics·Diana CostaAna Figueiras
Feb 23, 2021·Frontiers in Pharmacology·Agnese GagliardiDonato Cosco
Mar 13, 2021·Frontiers in Genetics·Mengqi Wang, Eveline M Ibeagha-Awemu
Mar 26, 2021·Molecular Cancer·Tina BriolayNicolas Boisgerault
Apr 4, 2021·Pharmaceutics·Henrique Faneca
Apr 8, 2021·Journal of Biochemical and Molecular Toxicology·Swati ChaudharyMahima Kaushik
Jun 22, 2021·Seminars in Cancer Biology·Serenella MediciMaria Antonietta Zoroddu
Jul 3, 2021·Pharmaceutics·Noha AttiaJose Luis Pedraz
Aug 11, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Meenu MehtaKamal Dua
Aug 22, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Monika NehraAjeet Kaushik

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Methods Mentioned

BETA
antisense oligonucleotides
transfection
antisense oligonucleotide
transgenic

Clinical Trials Mentioned

NCT02202564
NCT00012155
NCT00024661
NCT00024648
NCT00059605
NCT02354547
NCT04163094
NCT02410733
NCT00938574
NCT02191878

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