Gene Therapy in Cardiac Surgery: Clinical Trials, Challenges, and Perspectives

The Annals of Thoracic Surgery
Michael G KatzCharles R Bridges

Abstract

The concept of gene therapy was introduced in the 1970s after the development of recombinant DNA technology. Despite the initial great expectations, this field experienced early setbacks. Recent years have seen a revival of clinical programs of gene therapy in different fields of medicine. There are many promising targets for genetic therapy as an adjunct to cardiac surgery. The first positive long-term results were published for adenoviral administration of vascular endothelial growth factor with coronary artery bypass grafting. In this review we analyze the past, present, and future of gene therapy in cardiac surgery. The articles discussed were collected through PubMed and from author experience. The clinical trials referenced were found through the Wiley clinical trial database (http://www.wiley.com/legacy/wileychi/genmed/clinical/) as well as the National Institutes of Health clinical trial database (Clinicaltrials.gov).

References

Mar 15, 1997·The Journal of Clinical Investigation·M J MannV J Dzau
Oct 6, 1999·The Annals of Thoracic Surgery·J F SymesJ M Isner
Mar 20, 2002·Circulation·Cindy L GrinesRobert L Engler
Jun 6, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Johannes BonattiGünther Laufer
Jun 11, 2002·Journal of Interventional Cardiology·P R ValeK Rosenfield
May 29, 2003·The Journal of Thoracic and Cardiovascular Surgery·Frank W Sellke
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Oct 18, 2003·Journal of the American College of Cardiology·Cindy L GrinesUNKNOWN Angiogene GENe Therapy (AGENT-2) Study Group
Mar 25, 2005·Journal of Interventional Cardiology·John P ReillyJeffrey M Isner
Mar 26, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Giuseppe VassalliLudwig K von Segesser
Apr 9, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Duncan J StewartUNKNOWN NORTHERN Trial Investigators
Oct 10, 2009·Circulation Research·Rajesh GuptaDouglas W Losordo
Apr 6, 2011·The New England Journal of Medicine·Eric J VelazquezUNKNOWN STICH Investigators
Apr 6, 2011·The New England Journal of Medicine·Robert O BonowUNKNOWN STICH Trial Investigators
Jun 30, 2011·Basic Research in Cardiology·Antonio D LassalettaFrank W Sellke
Apr 27, 2012·Gene Therapy·T TangH Kirk Hammond
Sep 1, 2012·Biochemical Pharmacology·Shaina R EckhouseFrancis G Spinale
Oct 2, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Seppo Ylä-Herttuala
Sep 17, 2013·PloS One·Victoria FloreaClaudia O Rodrigues
Aug 27, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James N KochenderferSteven A Rosenberg

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Citations

Mar 8, 2018·American Journal of Physiology. Cell Physiology·Minglin PanAyako Makino
Aug 16, 2017·Human Gene Therapy·Johanna Lähteenvuo, Seppo Ylä-Herttuala
Jan 10, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Lihong PengQuan Wei
Apr 13, 2018·Journal of Cardiovascular Pharmacology and Therapeutics·Daryl RamaiSarath Reddy
Nov 5, 2019·The Journal of Thoracic and Cardiovascular Surgery·Michael G KatzAnthony S Fargnoli
Jan 24, 2019·The Journal of Thoracic and Cardiovascular Surgery·Michael G KatzRoger J Hajjar
Aug 17, 2021·Frontiers in Medicine·Zhi Jie LiYou Lang Zhou

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