PMID: 11325212Apr 28, 2001Paper

Gene therapy in heart disease

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
E TeigerS Adnot

Abstract

Application of gene therapy to the field of cardiovascular disorders has been the subject of intensive work over the recent period. Gene therapy for cardiovascular disorders is now fast developing with most therapies being devoted to the consequences (ischemia) rather than the causes of atherosclerotic diseases. Recent human clinical trials have shown that injection of naked DNA encoding vascular endothelial growth factor promotes collateral vessel development in patients with critical limb ischemia or chronic myocardial ischemia. Promising studies in animals have also fueled enthusiasm for treatment of human restenosis by gene therapy, but clinical applications are warranted. Application of gene transfer to other cardiovascular diseases will require the coordinated development of a variety of new technologies, as well as a better definition of cellular and gene targets.

References

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Citations

Jan 15, 2002·Journal of the American College of Cardiology·Harry C LoweLevon M Khachigian
Jan 25, 2002·Annals of the New York Academy of Sciences·B L MetcalfeM K Raizada
May 16, 2006·Vascular Pharmacology·Vladimir BobekKatarina Kolostova

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