Gene therapy strategies for hepatocellular carcinoma

Journal of Biomedical Science
Lih-Hwa Hwang

Abstract

Hepatocellular carcinoma (HCC) is one of the most frequent cancers worldwide. Effective therapy to this cancer is currently lacking, creating an urgent need for new therapeutic strategies for HCC. Gene therapy approach that relies on the transduction of cells with genetic materials, such as apoptotic genes, suicide genes, genes coding for antiangiogenic factors or immunomodulatory molecules, small interfering RNA (siRNA), or oncolytic viral vectors, may provide a promising strategy. The aforementioned strategies have been largely evaluated in the animal models with HCC or liver metastasis. Due to the diversity of vectors and therapeutic genes, being used alone or in combination, gene therapy approach may generate great beneficial effects to control the growth of tumors within the liver.

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Citations

Nov 12, 2013·The Surgical Clinics of North America·Emad H AshamR Mark Ghobrial
Apr 1, 2008·Surgical Oncology Clinics of North America·Travis KidnerYuman Fong
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Aug 23, 2012·Nucleic Acid Therapeutics·Mika KosakaLong-Cheng Li

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