Gene therapy strategies to block HIV-1 replication by RNA interference

Advances in Experimental Medicine and Biology
Elena Herrera-Carrillo, Ben Berkhout

Abstract

The cellular mechanism of RNA interference (RNAi) plays an antiviral role in many organisms and can be used for the development of therapeutic strategies against viral pathogens. Persistent infections like the one caused by the human immunodeficiency virus type 1 (HIV-1) likely require a durable gene therapy approach. The continuous expression of the inhibitory RNA molecules in T cells is needed to effectively block HIV-1 replication. We discuss here several issues, ranging from the choice of RNAi inhibitor and vector system, finding the best target in the HIV-1 RNA genome, alternatively by targeting host mRNAs that encode important viral cofactors, to the setup of appropriate preclinical test systems. Finally, we briefly discuss the relevance of this topic for other viral pathogens that cause a chronic infection in humans.

Citations

Dec 28, 2017·Viruses·Robert J Scarborough, Anne Gatignol
Apr 1, 2016·Current Opinion in HIV and AIDS·Chelsea SpraggKeith R Jerome
Nov 12, 2019·Briefings in Functional Genomics·Elena Herrera-CarrilloBen Berkhout
Feb 1, 2021·Virology Journal·Tugba Mehmetoglu-GurbuzAnjali Joshi

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