Gene Therapy: Targeting Cardiomyocyte Proliferation to Repopulate the Ischemic Heart.

Journal of Cardiovascular Pharmacology
Ayelén Emilce LópezPaola Locatelli

Abstract

Adult mammalian cardiomyocytes show scarce division ability, which makes the heart ineffective in replacing lost contractile cells after ischemic cardiomyopathy. In the past decades, there have been increasing efforts in the search for novel strategies to regenerate the injured myocardium. Among them, gene therapy is one of the most promising ones, based on recent and emerging studies that support the fact that functional cardiomyocyte regeneration can be accomplished by the stimulation and enhancement of the endogenous ability of these cells to achieve cell division. This capacity can be targeted by stimulating several molecules, such as cell cycle regulators, noncoding RNAs, transcription, and metabolic factors. Therefore, the proposed target, together with the selection of the vector used, administration route, and the experimental animal model used in the development of the therapy would determine the success in the clinical field.

Related Concepts

Related Feeds

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Frontiers in Bioengineering and Biotechnology
Andrew S Riching, Kunhua Song
Nihon rinsho. Japanese journal of clinical medicine
Yuji Itabashi, Keiichi Fukuda
Reviews of Physiology, Biochemistry and Pharmacology
David C Zebrowski, Felix B Engel
American Journal of Physiology. Heart and Circulatory Physiology
Marina LeoneFelix B Engel
© 2021 Meta ULC. All rights reserved