Gene therapy techniques for peripheral arterial disease

Cardiovascular and Interventional Radiology
Hannu I Manninen, Kimmo Mäkinen

Abstract

Somatic gene therapy is the introduction of new genetic material into selective somatic cells with resulting therapeutic benefits. Vascular wall and, subsequently, cardiovascular diseases have become an interesting target for gene therapy studies. Arteries are an attractive target for gene therapy since vascular interventions, both open surgical and endovascular, are well suited for minimally invasive, easily monitored gene delivery. Promising therapeutic effects have been obtained in animal models in preventing post-angioplasty restenosis and vein graft thickening, as well as increasing blood flow and collateral development in ischemic limbs. First clinical trials suggest a beneficial effect of vascular endothelial growth factor in achieving therapeutic angiogenesis in chronic limb ischemia and the efficacy of decoy oligonucleotides to prevent infrainguinal vein graft stenosis. However, further studies are mandatory to clarify the safety issues, to develop better gene delivery vectors and delivery catheters, to improve transgene expression, as well as to find the most effective and safe treatment genes.

Citations

Feb 15, 2003·The American Journal of Medicine·Kou-Gi ShyuPeiliang Kuan
Oct 6, 2004·Expert Opinion on Investigational Drugs·Sima T Tarzami, Jai Pal Singh
Apr 5, 2011·Journal of Vascular and Interventional Radiology : JVIR·Zhen W ZhuangMichael Simons
Oct 20, 2005·European Journal of Radiology·Hannu I Manninen, Xiaoming Yang
Jun 24, 2004·Asian Cardiovascular & Thoracic Annals·Lei YeEugene K W Sim
Nov 8, 2003·World Journal of Gastroenterology : WJG·Chao Zhang, Zhan-Kui Liu
Nov 21, 2002·Current Opinion in Lipidology·Saul Benedict Freedman
Aug 28, 2003·Diabetes Care·Andrew J M Boulton, David G Armstrong

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