Gene transcription of TLR2, TLR4, LPS ligands and prostaglandin synthesis enzymes are up-regulated in canine uteri with cystic endometrial hyperplasia-pyometra complex

Journal of Reproductive Immunology
E SilvaL Mateus

Abstract

Escherichia coli (E. coli) is the most frequent bacterium isolated in cases of cystic endometrial hyperplasia-pyometra complex, the most frequent endometrial disorder in the bitch. Toll-like receptors (TLRs) play an essential role in the innate immune system. The aim of this study was to compare transcription of genes encoding TLR2, TLR4 and LPS ligands (CD14, MD-2, LBP), prostaglandin synthesis enzymes (COX1, COX2, PGES1 and PGFS), and to compare COX1 and COX2 protein expression and PGE(2) and PGF(2alpha) endometrial content in the endometrium of canine diestrous uteri with (n=7) or without (n=7) pyometra. All cases of pyometra were hyperplastic and E. coli was the only isolated bacteria, while diestrous normal uteri did not present signs of cystic endometrial hyperplasia and were negative for bacteriology. Except for COX1, transcription of all genes was significantly higher in pyometra than in normal endometria. COX1 protein was observed in both normal and pyometra uteri, but COX2 protein was only present in pyometra cases. Endometrial PGE(2) and PGF(2alpha) content were significantly higher in pyometra than in normal diestrous endometria. In conclusion, data obtained in this study provides evidence that pyometra-isolated E. ...Continue Reading

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Citations

May 27, 2014·Veterinary Immunology and Immunopathology·Marcello P RiggioDavid Bennett
Jun 12, 2016·Reproductive Biology·Ewelina Jursza-Piotrowska, Marta J Siemieniuch
Jul 26, 2011·Veterinary Immunology and Immunopathology·Kenji TakasawaHiroshi Kamata
Jan 4, 2013·Reproduction in Domestic Animals = Zuchthygiene·R Hagman
Aug 21, 2013·Veterinary Microbiology·Luisa MateusElisabete Silva
Nov 21, 2014·PloS One·Daniel MurtaLuís Lopes-da-Costa
Nov 11, 2016·Veterinary Research·Sofia HenriquesLuisa Mateus
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Aug 18, 2017·Reproduction in Domestic Animals = Zuchthygiene·R Hagman
Jun 21, 2014·Reproduction in Domestic Animals = Zuchthygiene·F FieniA Gogny
Aug 18, 2017·Reproduction in Domestic Animals = Zuchthygiene·M Christoffersen, Mht Troedsson

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