Gene transfer of interleukin-4 delays acute rejection of splenic allografts in rats

Transplantation Proceedings
H JiangX Sun

Abstract

Spleen transplantation is the treatment of choice for some diseases, such as hemophilia A. However, the risk and intensity of rejection after spleen transplantation is greater and more difficult to control than other types of transplant. In the present study, we demonstrated that perfusion of IL-4 expression plasmids into donor spleens pretransplantation led to overexpression of IL-4 and downregulation of IFN-gamma in situ, associated with delayed acute rejection of the allograft. Gene transfer of IL-4 may represent a potential therapeutic approach to induce tolerance to splenic allografts.

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Citations

Oct 24, 2006·The Journal of Surgical Research·Hongchi JiangXueying Sun
May 26, 2010·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Yuetang MiXueying Sun
Jan 9, 2008·International Journal of Immunopathology and Pharmacology·B OrsiniM M D' Elios

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