Gene Variation of Endoplasmic Reticulum Aminopeptidases 1 and 2, and Risk of Blood Pressure Progression and Incident Hypertension among 17,255 Initially Healthy Women

International Journal of Genomics
Robert Y L ZeeJose R Romero

Abstract

Recent studies have demonstrated the importance of endoplasmic reticulum aminopeptidase (ERAP) in blood pressure (BP) homeostasis. To date, no large prospective, genetic-epidemiological data are available on genetic variation within ERAP and hypertension risk. The association of 45 genetic variants of ERAP1 and ERAP2 was investigated in 17,255 Caucasian female participants from the Women's Genome Health Study. All subjects were free of hypertension at baseline. During an 18-year follow-up period, 10,216 incident hypertensive cases were identified. Multivariable linear, logistic, and Cox regression analyses were performed to assess the relationship of genotypes with baseline BP levels, BP progression at 48 months, and incident hypertension assuming an additive genetic model. Linear regression analyses showed associations of four tSNPs (ERAP1: rs27524; ERAP2: rs3733904, rs4869315, and rs2549782; all p < 0.05) with baseline systolic BP levels. Three tSNPs (ERAP1: rs27851, rs27429, and rs34736, all p < 0.05) were associated with baseline diastolic BP levels. Multivariable logistic regression analysis showed that ERAP1 rs27772 was associated with BP progression at 48 months (p = 0.0366). Multivariable Cox regression analysis showed ...Continue Reading

References

Jun 12, 2003·The Journal of Biological Chemistry·Toshihiro TaniokaMasafumi Tsujimoto
Jun 27, 2003·Lancet·Mark CaulfieldUNKNOWN MRC British Genetics of Hypertension Study
Sep 19, 2003·BMC Cardiovascular Disorders·Par HallbergHakan Melhus
Mar 9, 2005·The New England Journal of Medicine·Paul M RidkerJulie E Buring
Jul 7, 2005·JAMA : the Journal of the American Medical Association·I-Min LeeJulie E Buring
Jun 23, 2006·The Journal of Biological Chemistry·Yoshikuni GotoMasafumi Tsujimoto
Sep 28, 2007·Nature Genetics·Matthew D MailmanStephen T Sherry
Dec 27, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anna TarantaFrancesco Emma
Jul 7, 2009·Human Genetics·Matthew P JohnsonEric K Moses
Jun 7, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Cuneyt K BuharaliogluKafait U Malik
Sep 13, 2011·Nature·UNKNOWN International Consortium for Blood Pressure Genome-Wide Association StudiesToby Johnson
Nov 18, 2011·American Journal of Hypertension·Luminita H PojogaJose R Romero
Sep 4, 2012·International Journal of Molecular Sciences·Loredana CifaldiDoriana Fruci
May 30, 2013·Nature Genetics·UNKNOWN GTEx Consortium
Dec 4, 2013·Nucleic Acids Research·Kimberly A TrykaMichael Feolo
Feb 28, 2014·European Journal of Heart Failure·Mauro GoriUNKNOWN PARAMOUNT Investigators
May 12, 2015·Molecular Cell·Chihiro HisatsuneKatsuhiko Mikoshiba
Nov 18, 2016·MMWR. Morbidity and Mortality Weekly Report·Rikita MeraiPhoebe Thorpe
Nov 26, 2016·The Medical Clinics of North America·Walmor C De Mello
Dec 3, 2016·Nucleic Acids Research·Kira M WongStephen T Sherry
Jan 31, 2017·Nature Genetics·Helen R WarrenUNKNOWN UK Biobank CardioMetabolic Consortium BP working group

❮ Previous
Next ❯

Citations

Nov 15, 2018·Frontiers in Immunology·José A López de Castro
Feb 6, 2020·Biological & Pharmaceutical Bulletin·Masafumi TsujimotoYoshikuni Goto
Feb 12, 2019·Frontiers in Immunology·Fabiana PaladiniRosa Sorrentino
Aug 23, 2020·International Journal of Molecular Sciences·Ombretta MelaiuDoriana Fruci
Feb 12, 2021·International Journal of Molecular Sciences·Silvia D'AmicoDoriana Fruci

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

R
SAS

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.