PMID: 9166580Jun 1, 1997Paper

Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain

Mammalian Genome : Official Journal of the International Mammalian Genome Society
D W ThreadgillT Magnuson

Abstract

The 129 mouse is the most widely used strain in gene targeting experiments. However, numerous substrains exist with demonstrable physiological differences. In this study a set of simple sequence length polymorphisms (SSLPs) was used to determine the relatedness of selected 129 substrains. 129/SvJ was significantly different from the other 129 substrains and is more accurately classified as a recombinant congenic strain (129cX/Sv), being derived from 129/Sv and an unknown strain. This mixed genetic background could complicate gene targeting experiments by reducing homologous recombination efficiency when constructs and ES cells are not derived from the same 129 substrain. Additionally, discrepancies due to different genetic backgrounds may arise when comparing phenotypes of genes targeted in different 129-derived ES cell lines.

References

Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·H te RieleA Berns
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B H KollerO Smithies
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A GosslerR Kemler
Jun 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·T SakuraiM Noguchi
Mar 14, 1996·Nature·W F DietrichT J O'Connor
Jan 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·G B CollinJ H Nadeau
Jun 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D W ThreadgillT Magnuson
Nov 1, 1954·Proceedings of the National Academy of Sciences of the United States of America·L C Stevens, C C Little

❮ Previous
Next ❯

Citations

Aug 3, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M AugustinS Wattler
Jul 18, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Morag RobertsonIan Chambers
May 26, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jennifer DackorDavid W Threadgill
Jun 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D W ThreadgillT Magnuson
Mar 21, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Y YouJ Schimenti
Dec 17, 2008·Pflügers Archiv : European journal of physiology·Isabelle RuberaFriedrich Beermann
Oct 8, 2005·Virchows Archiv : an International Journal of Pathology·Susanne KorffBoris Tomislav Ivandic
Feb 7, 2004·Archives of Gerontology and Geriatrics·Shin TanakaTamio Ohno
Aug 31, 1999·Neurobiology of Aging·J M HengemihleD K Ingram
Oct 10, 1998·Pain·Jeffrey S Mogil, Judith E Grisel
May 4, 2001·Hearing Research·R R DavisL C Erway
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Candice ContetBrigitte L Kieffer
Sep 28, 2005·Oncogene·H LiI B Weinstein
Jul 18, 2002·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·I BanakhJ W Goding
Oct 13, 2011·DNA and Cell Biology·Chiao-Ling LoAmy C Lossie
Mar 21, 2006·ILAR Journal·Carol Cutler Linder
Mar 10, 2001·Genes & Development·D M AllenC Barlow
Sep 3, 2004·Genome Research·Petko M PetkovMichael V Wiles
Oct 9, 2007·Diabetes, Obesity & Metabolism·M A Magnuson, J S Burlison
May 13, 1999·Immunological Reviews·C AmadouK F Lindahl
Dec 24, 2009·Infection and Immunity·Cristiano G MoreiraVanessa Sperandio
May 30, 2003·Molecular and Cellular Biology·Els C M Brinkman-Van der LindenAjit Varki
Feb 1, 2007·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Steven E DominoElizabeth A Hurd
Jul 30, 2005·Blood·Mondira KunduP Paul Liu
Feb 5, 2011·BMC Immunology·Muthuvel ArumugamSimon P Hogan
Jun 7, 2006·Genes & Genetic Systems·Masato OhtsukaHidetoshi Inoko
Jan 9, 2007·PLoS Genetics·Timothy A GraubertTimothy J Ley
Dec 13, 2007·PloS One·Luis M Valor, Seth G N Grant
Mar 28, 2013·PloS One·Kalani HalemanoMario L Santiago
May 7, 2013·PloS One·Weicheng RenInga-Lill Mårtensson
Dec 21, 2006·Genetics·Isabel Rubio-AliagaMartin Hrabé de Angelis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved