Gene/environment causes of cleft lip and/or palate

Clinical Genetics
J C Murray

Abstract

Craniofacial anomalies, and in particular cleft lip and palate, are major human birth defects with a worldwide frequency of 1 in 700 and substantial clinical impact. A wide range of studies in developmental biology has contributed to a better knowledge of how both genes and environmental exposures impact head organogenesis. Specific causes have now been identified for some forms of cleft lip and palate, and we are at the beginning of a time in which the common nonsyndromic forms may also have specific etiologies identified. Mouse models have an especially important role in disclosing cleft etiologies and providing models for environmental cotriggers or interventions. An overview of the gene-environment contributions to nonsyndromic forms of clefting and their implications for developmental biology and clinical counseling is presented.

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Jan 15, 2008·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Mary M JenkinsMargaret A Honein
Jan 10, 2008·Plastic and Reconstructive Surgery·John A van AalstMichael Sadove
Apr 9, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shuping GuYiPing Chen
Apr 3, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Min ShiJeffrey C Murray
May 15, 2008·American Journal of Medical Genetics. Part a·Renato MenezesAlexandre R Vieira
May 10, 2005·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·V C DhulipalaC S Reddy
Jun 1, 2005·Plastic and Reconstructive Surgery·Barry L EppleyA Michael Sadove
Oct 10, 2009·The Journal of Craniofacial Surgery·Soung Min KimJin Young Choi
Sep 22, 2010·The Journal of Craniofacial Surgery·Zöe Powis, Robert P Erickson
Aug 13, 2005·American Journal of Medical Genetics. Part a·Susan H BlantonJacqueline T Hecht
Sep 30, 2005·The Journal of Craniofacial Surgery·Cenk TokatYalcin Akin
Nov 18, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rulang JiangAndrew C Lidral
Oct 26, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alexandra S KnightMichael J Dixon
Mar 30, 2019·Molecular Genetics & Genomic Medicine·Nurul Syazana Mohamad ShahAhmad Sukari Halim
Nov 1, 2018·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Qiang ZhangZhengwei Yuan
May 5, 2018·Scientific Reports·Amanda K PowersJoshua B Gross
Jun 7, 2019·Disease Models & Mechanisms·Safiye E SarperTakashi Yamashiro
Dec 16, 2005·Molecular Pharmacology·Tami L ThomaeChristopher A Bradfield
Dec 11, 2019·The Journal of Craniofacial Surgery·Mekonen EsheteWakgari Deressa
Jan 18, 2020·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Yah-Huei Wu-ChouLun-Jou Lo
Dec 13, 2017·American Journal of Medical Genetics. Part a·Emily R GallagherMichael L Cunningham
Oct 26, 2012·Journal of Perinatal Medicine·Bénédicte MichelOlivia Williams
Aug 14, 2020·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Jeremy V LynnSteven R Buchman
Jun 27, 2007·Southern Medical Journal·Dominik D Alexander
Nov 14, 2018·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Yah-Huei Wu-ChouLun-Jou Lo
Jan 27, 2019·Nature Reviews. Drug Discovery·Joseph H Nadeau, Johan Auwerx
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Mohammad Khursheed Alam, Ahmed Ali Alfawzan
May 9, 2006·Cadernos de saúde pública·Martha Lopes Schuch de CastroMaria da Graça Martino-Röth
Feb 19, 2010·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Tuomas KlockarsJorma Rautio
Jan 31, 2016·The Journal of Biological Chemistry·Huarong HuangZunyi Zhang
Feb 19, 2016·Birth Defects Research. Part A, Clinical and Molecular Teratology·Juan Antonio GiliJorge Santiago López-Camelo
Jun 10, 2016·Molecular Medicine Reports·Xingang YuanYuexian Fu
Aug 28, 2020·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Teresa KruseBert Braumann
Jun 29, 2011·Revista da Escola de Enfermagem da U S P·Ana Paula Vanz, Nair Regina Ritter Ribeiro
Jul 22, 2005·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Linda Merritt
Jan 31, 2018·The Journal of Craniofacial Surgery·Alexandre R VieiraIêda M Orioli
Jul 8, 2020·Human & Experimental Toxicology·X-H WangL-Y Meng
Feb 24, 2009·Experimental Biology and Medicine·Wenli YuKathy K H Svoboda
Nov 24, 2016·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Liene Smane-FilipovaIlze Akota
Jul 27, 2018·Scientific Reports·Safiye E SarperTakashi Yamashiro
Sep 21, 2013·The Journal of Clinical Pediatric Dentistry·Patricia N TannureJosé Mauro Granjeiro
Jun 24, 2017·Orthodontics & Craniofacial Research·E L DurhamJ J Cray
May 16, 2018·The Journal of Craniofacial Surgery·Arezoo JahanbinMostafa Abtahi
May 24, 2018·Journal of Applied Oral Science : Revista FOB·Erika Calvano KüchlerAlexandre R Vieira
Oct 29, 2020·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Ahmed M El SerganiSeth M Weinberg
Oct 26, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Devi Sewvandini Atukorala Atukorallaya, Ravindra Kumar Ratnayake
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Marcella MartinelliLuca Scapoli
Aug 29, 2020·The Journal of Craniofacial Surgery·Shahistha ParveenSrinivas Gosla Reddy
Dec 29, 2020·PloS One·Juliane R LavôrAlexandre R Vieira
Jul 30, 2020·The British Journal of Oral & Maxillofacial Surgery·J XuY Chen
Jan 17, 2021·Clinical and Experimental Dental Research·Khalid AlqahtaniReinhilde Jacobs
Jan 21, 2021·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Lisanne M van der LekChantal M Mouës-Vink
Feb 3, 2021·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Morgan WishneyAlexandra K Papadopoulou
Jan 5, 2021·Global Medical Genetics·Mahamad Irfanulla Khan, Prashanth Cs
Feb 23, 2021·European Journal of Orthodontics·João Paulo Schwartz, Daniela Gamba Garib

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Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.