General anaesthesia-induced anaphylaxis: impact of allergy testing on subsequent anaesthesia

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Axel TrautmannCornelia S Seitz

Abstract

Immunoglobulin E-mediated allergy to drugs and substances used during general anaesthesia as well as non-allergic drug hypersensitivity reactions may account for anaesthesia-induced anaphylaxis. As IgE-mediated anaphylaxis is a potentially life-threatening reaction, identification of the culprit allergen is essential to avoid anaphylaxis recurrence during subsequent general anaesthesia. To study whether preventive recommendations derived from allergy testing after intraoperative anaphylaxis were followed in subsequent general anaesthesia. Results of standardized allergy testing after anaesthesia-induced anaphylaxis and outcome of subsequent general anaesthesia were analysed retrospectively. Fifty-three of 107 patients were diagnosed with IgE-mediated allergy to a drug or substance used during general anaesthesia, and 54 patients were test negative. Twenty-eight of 29 allergy patients tolerated subsequent general anaesthesia uneventfully. One patient with cefazolin allergy suffered from anaphylaxis recurrence due to accidental reapplication of cefazolin. Twenty-two of 24 test-negative patients tolerated subsequent general anaesthesia, whereas two patients again developed anaphylaxis despite pre-medication regimens. Our results c...Continue Reading

References

Dec 12, 2001·Acta Anaesthesiologica Scandinavica·L H GarveyB Husum
Sep 10, 2003·Anesthesiology·Paul Michel MertesUNKNOWN Groupe d'Etudes des Réactions Anaphylactoïdes Peranesthésiques
Aug 19, 2004·The Journal of Allergy and Clinical Immunology·Simon G A Brown
Apr 27, 2005·Anesthesiology·Torkel HarboeErik Florvaag
May 21, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·P DewachterP-M Mertes
Feb 17, 2009·International Archives of Allergy and Immunology·Cornelia S SeitzAxel Trautmann
Sep 9, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C S SeitzA Trautmann
Mar 9, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P W EwanUNKNOWN BSACI
Feb 12, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Cornelia S SeitzAxel Trautmann
Apr 19, 2011·The Journal of Allergy and Clinical Immunology·Paul Michel MertesUNKNOWN Groupe d'Etudes des Réactions Anaphylactoïdes Peranesthésiques
Jun 8, 2011·Allergy·D G EboI Terreehorst
Nov 19, 2011·Acta Anaesthesiologica Scandinavica·S BacheL H Garvey
May 2, 2014·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Cornelia S SeitzAxel Trautmann
May 23, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J LeysenD G Ebo
Jun 26, 2014·Allergy·A P UyttebroekD G Ebo
Aug 6, 2014·The Journal of Allergy and Clinical Immunology·Sigurd Broesby-OlsenUNKNOWN Odense Research Centre for Anaphylaxis
Jan 13, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Autumn C GuyerAleena Banerji
Jan 13, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Alexei Gonzalez-EstradaDavid M Lang

❮ Previous
Next ❯

Citations

May 21, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W EgnerN J N Harper
Apr 15, 2018·Allergy·N PetitpainUNKNOWN French Network of Regional Pharmacovigilance Centres
Jan 10, 2018·Anaesthesia·K Patton, D C Borshoff
Feb 23, 2020·Case Reports in Anesthesiology·Manzo SuzukiHiroyasu Bito
Nov 23, 2016·Case Reports in Immunology·R A BansalA S Bansal
Jul 6, 2018·Allergo Journal International·Wolfgang Pfützner, Knut Brockow
Dec 10, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Philipp SchrüferAxel Trautmann
Nov 29, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Aleena BanerjiKimberly G Blumenthal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.

Related Papers

Asia Pacific Allergy
Kumiya SugiyamaYasutsugu Fukushima
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
E GómezC Mayorga
© 2022 Meta ULC. All rights reserved