General and Genetic Toxicology of Guayusa Concentrate (Ilex guayusa)

International Journal of Toxicology
Robert W KappRichard Kraska

Abstract

Tea from the leaves of guayusa (Ilex guayusa) has a long history of consumption by Ecuadorian natives in regions where the plant is indigenous. The tea contains the methylxanthines caffeine and theobromine as well as chlorogenic acids, flavonoids, and sugars. Various studies were performed to evaluate the general and genetic toxicology of a standardized liquid concentrate of guayusa (GC). Guayusa concentrate was found to be negative in in vitro genotoxicity tests including the Ames test and a chromosome aberration study in human lymphocytes. The oral median lethal dose (LD50) of GC was >5,000 mg/kg for female rats. Guayusa concentrate was administered to male and female rats in a 90-day subchronic study at 1,200, 2,500, and 5,000 mg/kg/d of GC and a caffeine-positive control at 150 mg/kg/d corresponding to the amount of caffeine in the high-dose GC group. Effects observed in the GC-treated groups were comparable to those in the caffeine control group and included reductions in body weights, food efficiency, triglycerides values, and fat pad weights and increases in blood chemistry values for serum aspartate aminotransferase, serum alanine aminotransferase, and cholesterol and adaptive salivary gland hypertrophy. No signs of inc...Continue Reading

References

Feb 1, 1978·Pediatric Research·R J Grand, M I Schay
Jan 26, 1978·The New England Journal of Medicine·D RobertsonJ A Oates
May 1, 1991·Journal of Ethnopharmacology·W H LewisD Fast
Aug 1, 1991·Pharmacology, Biochemistry, and Behavior·B ZimmerbergJ M Weider
Jun 1, 1990·Molecular and Cellular Biochemistry·M G Humphreys-BeherC A Schneyer
Jul 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B Stavric
Dec 1, 1986·Journal of Nutritional Science and Vitaminology·K MuramatsuY Hara
Jul 1, 1987·Journal of Ethnopharmacology·F Alikaridis
Mar 1, 1986·The American Journal of Clinical Nutrition·A G Dulloo, D S Miller
Dec 1, 1985·International Journal of Sports Medicine·A R Wilcox
Sep 1, 1983·Clinical and Experimental Pharmacology & Physiology·M F KennedyD H Barkla
May 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J H Gans
May 1, 1981·Clinical Science·R T JungB A Callingham
Jan 1, 1982·Medicine and Science in Sports and Exercise·A R Wilcox
Jun 1, 1995·The American Journal of Physiology·P J ArcieroE T Poehlman
Oct 1, 1994·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·T M Chou, N L Benowitz
Jun 1, 1994·Regulatory Toxicology and Pharmacology : RTP·S M D'Ambrosio
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·K R PurushothamC A Schneyer
Mar 1, 1993·Preventive Medicine·B D'AvanzoC La Vecchia
Jul 5, 1996·Mutation Research·L S AgapovaB P Kopnin
Feb 24, 2001·American Journal of Epidemiology·S H JeeM J Klag
Jun 27, 2001·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·T Andersen, J Fogh
Nov 3, 2001·The Journal of Allergy and Clinical Immunology·D M Essayan
May 30, 2002·Circulation·Kenneth J MukamalMurray A Mittleman
Jan 10, 2003·Food Additives and Contaminants·P NawrotM Feeley
Jan 29, 2003·The Journal of Nutritional Biochemistry·Soo Bong ChoiSunmin Park
Jul 29, 2003·Journal of Nutritional Science and Vitaminology·Koutarou MuroyamaMasamitsu Miyoshi
Aug 1, 1962·The American Journal of Physiology·C A SCHNEYER
Dec 23, 2004·Journal of Agricultural and Food Chemistry·Pin-Der DuhLee-Wen Chang
Jan 7, 2005·Journal of the American Dietetic Association·Carol D FraryMin Qi Wang
Jul 5, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Raymond CooperDorothy M Morré
Jul 28, 2005·Cell and Tissue Research·Tannin J FujaIngo R Titze
Sep 1, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Raymond CooperDorothy M Morré
Nov 25, 2005·Bioscience, Biotechnology, and Biochemistry·Kazuo Kobayashi-HattoriToshichika Takita
Jan 13, 2006·Molecular Nutrition & Food Research·Jen-Kun Lin, Shoei-Yn Lin-Shiau

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Citations

Sep 17, 2016·Journal of Toxicology·Amy ClewellIlona Pasics Szakonyiné
Feb 12, 2017·Journal of the Science of Food and Agriculture·Almudena García-RuizJenny Ruales
Aug 2, 2019·Critical Reviews in Food Science and Nutrition·Graham Wise, Adam Negrin
Jan 9, 2020·Journal of Toxicology·Timothy S MurbachIlona Pasics Szakonyiné
Jul 10, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Zhong HanWei Yang

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Methods Mentioned

BETA
Assay
chromosomal aberration
blood collection
dissection
light microscopy
chromosomal aberrations

Software Mentioned

Provantis

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