General aspects of muscle glucose uptake

Anais Da Academia Brasileira De Ciências
Rafael O AlvimPaulo C J L Santos

Abstract

Glucose uptake in peripheral tissues is dependent on the translocation of GLUT4 glucose transporters to the plasma membrane. Studies have shown the existence of two major signaling pathways that lead to the translocation of GLUT4. The first, and widely investigated, is the insulin activated signaling pathway through insulin receptor substrate-1 and phosphatidylinositol 3-kinase. The second is the insulin-independent signaling pathway, which is activated by contractions. Individuals with type 2 diabetes mellitus have reduced insulin-stimulated glucose uptake in skeletal muscle due to the phenomenon of insulin resistance. However, those individuals have normal glucose uptake during exercise. In this context, physical exercise is one of the most important interventions that stimulates glucose uptake by insulin-independent pathways, and the main molecules involved are adenosine monophosphate-activated protein kinase, nitric oxide, bradykinin, AKT, reactive oxygen species and calcium. In this review, our main aims were to highlight the different glucose uptake pathways and to report the effects of physical exercise, diet and drugs on their functioning. Lastly, with the better understanding of these pathways, it would be possible to ...Continue Reading

References

Mar 1, 1991·The American Journal of Physiology·J H YounJ O Holloszy
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·S LundO Pedersen
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·D L RothmanG I Shulman
Jan 1, 1996·Reviews of Physiology, Biochemistry and Pharmacology·J O Holloszy, P A Hansen
Jul 22, 1999·The New England Journal of Medicine·P R Shepherd, B B Kahn
Feb 17, 2000·The Journal of Clinical Investigation·K CusiL J Mandarino
Jun 8, 2000·Annals of the New York Academy of Sciences·J K HammS R Farmer
Jul 13, 2000·Biochemical and Biophysical Research Communications·N FujiiL J Goodyear
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·Z P ChenB E Kemp
Sep 5, 2001·The Journal of Physiology·E A RichterJ F Wojtaszewski
Oct 17, 2001·The Journal of Clinical Investigation·G ZhouD E Moller
Dec 26, 2001·Hypertension·I DukaH Gavras
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·Edward O OjukaJohn O Holloszy
Sep 7, 2002·Hypertension·Tetsuya ShiuchiMasatsugu Horiuchi
Dec 19, 2002·American Journal of Physiology. Endocrinology and Metabolism·Jorgen F P WojtaszewskiErik A Richter
Jan 28, 2003·Biochemical Society Transactions·B E KempL A Witters
Jan 28, 2003·Journal of Applied Physiology·Shin TeradaIzumi Tabata
Mar 15, 2003·The Journal of Biological Chemistry·Hiroyuki SanoGustav E Lienhard
Jun 26, 2003·European Journal of Endocrinology·Takashi TanakaYukihiko Adachi
Jun 28, 2003·FEBS Letters·D Grahame HardieEmma R Hudson
Jul 17, 2003·Acta Physiologica Scandinavica·N Musi, L J Goodyear

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Citations

Feb 6, 2016·Age·Magdalena Jura, Leslie P Kozak
Oct 4, 2017·Journal of Physiology and Biochemistry·Hakam Alkhateeb, Esam Qnais
Jul 10, 2019·Journal of Internal Medicine·R Loera-ValenciaB Winblad
May 7, 2019·Genes, Brain, and Behavior·Marleen H M de GrootJoseph S Takahashi
Sep 25, 2020·Clinical Nuclear Medicine·Pierre MeneretClémence Pontoizeau
Mar 9, 2017·Journal of Alzheimer's Disease : JAD·Prashant BharadwajGiuseppe Verdile
Aug 14, 2019·American Journal of Physiology. Endocrinology and Metabolism·Amanda J PageGary A Wittert
Jul 30, 2019·Journal of Food Biochemistry·Ochuko L ErukainureMd Shahidul Islam
Nov 21, 2020·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Matthew Goff, Guoxun Chen
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·SaiSantosh Babu KomakulaShashi Singh
Feb 1, 2021·Molecular and Cellular Biochemistry·Trang Thi Huyen Dang, Jong Won Yun
Feb 13, 2021·International Journal of Molecular Sciences·Itziar EseberriMaria P Portillo

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