PMID: 11312930Apr 21, 2001Paper

General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia

Journal of Natural Products
E NavarroC Perez

Abstract

Cytotoxicity, acute toxicity, and general pharmacological effects in mice of an arylnaphthalene lignan isolated from Jisticia hyssopifolia were studied. Elenoside was cytotoxic to human cancer cell lines in a range of concentrations from 10(-5) to 10(-4)M. It has an LD(50), ip in mice, of 305 mg/kg and central depressive properties at doses of 25, 50, and 100 mg/kg. Thus, elenoside appears to be a sedative with broad spectrum cytotoxicity.

References

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Citations

Jan 26, 2013·Chemical Reviews·Bagher Eftekhari-SisAli Akbari
Nov 29, 2005·Natural Product Reports·Muhammad SaleemYong Sup Lee
Nov 26, 2010·Natural Product Research·Xiao-Ling XieXiao Chen
Aug 21, 2002·Biological & Pharmaceutical Bulletin·Eduardo NavarroCarlos Hernández-Calzadilla
Jul 1, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Eduardo NavarroR Navarro
Oct 27, 2004·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E NavarroC Pérez
Sep 4, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Li LangJin Huang
Apr 12, 2018·Organic & Biomolecular Chemistry·Kashmiri NeogPranjal Gogoi
Oct 16, 2013·Angewandte Chemie·Upendra SharmaDebabrata Maiti
Nov 30, 2006·World Journal of Gastroenterology : WJG·E NavarroE Jorge
Nov 18, 2016·Organic & Biomolecular Chemistry·Primali V Navaratne, Alexander J Grenning
Oct 3, 2015·Chemistry : a European Journal·Sujuan WangJinchong Xiao
Nov 30, 2011·The Journal of Organic Chemistry·Leire AriasFernando P Cossío
May 23, 2020·The Journal of Organic Chemistry·Zhe ZhangYong-Min Liang

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