PMID: 3645272Jan 1, 1987Paper

General mechanism of chronic diseases

Medical Hypotheses
A Yabrov


In a human, the cells function adequately to the needs of the organism, and to their own needs. Consequently, adequate cell function is comprised of the organism-oriented, and cell-oriented functions. It is suggested that an independent stage in the pathogenesis of a chronic disease exists which so far has not been considered. This is the disturbance of the cell-oriented function of the cells involved. This initial stage may last for years and decades, whereas function of the organ remains preserved. Organism-oriented cellular function appears to become involved in the pathologic process long after the disease has actually started. At this time the cells themselves are severely impaired, and as a result a disease acquires its progressive, irreversible course. Pathogenesis of atherosclerosis is considered as an example of the above-mentioned developments.


Jan 1, 1979·Physiological Reviews·J Chamley-CampbellR Ross
Mar 1, 1978·AJR. American Journal of Roentgenology·R Greene
Jul 1, 1977·Archives of Internal Medicine·E D Robin
Nov 2, 1976·Biochemistry·S J Shattil, R A Cooper
Nov 11, 1976·Clinical and Experimental Pharmacology & Physiology·R H FagardA C Guyton
Mar 1, 1976·The Journal of Clinical Investigation·A D MorrisonA I Winegrad
Dec 1, 1986·Medical Hypotheses·A Yabrov
Apr 1, 1985·Experimental and Molecular Pathology·G R Campbell, J H Campbell
Mar 1, 1985·Science·G Kolata
Mar 1, 1985·Medical Hypotheses·D Nguyen
Jun 1, 1971·The Journal of Cell Biology·C E Devine, A P Somlyo
Jul 15, 1971·European Journal of Biochemistry·J Seelig, W Hasselbach
Feb 1, 1974·Journal of Theoretical Biology·D Papahadjopoulos
Jul 5, 1974·Nature·S Bannai, J R Sheppard
Jun 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·E P Benditt, J M Benditt
Sep 1, 1972·Atherosclerosis·E S MorrisonJ Frick
Feb 25, 1973·Journal of Molecular Biology·A K Bandyopadhyay, M P Deutscher
May 1, 1973·Atherosclerosis·C HeughanT K Hunt
Sep 1, 1968·Journal of Atherosclerosis Research·K KjeldsenP Astrup
Oct 1, 1965·Experimental and Molecular Pathology·M D HaustJ U Balis
Nov 1, 1984·Basic Research in Cardiology·H G Glitsch
Apr 17, 1982·British Medical Journal·J L DayC N Simpson
Jun 30, 1984·Lancet·M G MarmotL Bulusu
Jan 1, 1982·Annals of the New York Academy of Sciences·P Mitchell, W H Koppenol
Jan 1, 1982·Annals of the New York Academy of Sciences·J T Penniston
Dec 1, 1984·Experimental and Molecular Pathology·A GenoveseM Condorelli
Jun 1, 1981·Medical Hypotheses·G R Campbell, J H Chamley-Campbell
Jan 1, 1982·Annals of the New York Academy of Sciences·T HenriksenD Steinberg

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Dec 1, 1986·Medical Hypotheses·A Yabrov
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