PMID: 3645272Jan 1, 1987Paper

General mechanism of chronic diseases

Medical Hypotheses
A Yabrov

Abstract

In a human, the cells function adequately to the needs of the organism, and to their own needs. Consequently, adequate cell function is comprised of the organism-oriented, and cell-oriented functions. It is suggested that an independent stage in the pathogenesis of a chronic disease exists which so far has not been considered. This is the disturbance of the cell-oriented function of the cells involved. This initial stage may last for years and decades, whereas function of the organ remains preserved. Organism-oriented cellular function appears to become involved in the pathologic process long after the disease has actually started. At this time the cells themselves are severely impaired, and as a result a disease acquires its progressive, irreversible course. Pathogenesis of atherosclerosis is considered as an example of the above-mentioned developments.

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Citations

Dec 1, 1986·Medical Hypotheses·A Yabrov
Jun 15, 2004·Medical Hypotheses·Alexander Yabrov, Yuri Okunev
Jul 28, 2005·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·I BraghettoF Undurraga
Feb 1, 1995·Journal of Clinical Periodontology·N G Clarke, R S Hirsch

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