PMID: 1233210Feb 28, 1975

General pharmacokinetic equations for linear mammillary models with drug absorption into peripheral compartments

European Journal of Clinical Pharmacology
D P VaughanM Mitchard

Abstract

General equations are derived for the disposition functions of any compartment in a linear mammillary model, when the system input occurs into a peripheral compartment. Laplace transforms and matrix algebra are used to derive these equations. Equations describing the time-course of a drug in any compartment are readily obtainable using disposition and input functions.

Citations

Oct 1, 1974·The Journal of Pharmacy and Pharmacology·D P Vaughan, A H Beckett
Feb 1, 1972·The Journal of Pharmacy and Pharmacology·A H Beckett, J A Salmon
Dec 1, 1968·Journal of Pharmaceutical Sciences·T L LooB J Shepard
Apr 1, 1969·Circulation·G A EwyF I Marcus
Apr 1, 1969·Journal of Pharmaceutical Sciences·G LevyW J Jusko
Sep 1, 1965·The Bulletin of Mathematical Biophysics·A RESCIGNO, G Segre
Mar 1, 1964·The Bulletin of Mathematical Biophysics·A RESCIGNO

Related Concepts

Intestinal Absorption
Mathematics
Pharmaceutical Preparations

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