PMID: 6989685Jan 1, 1980Paper

General practitioners' evaluation of side-effects and efficacy of oxamethacin as compared with indomethacin

The Journal of International Medical Research
J Polderman, M Colon


Sixteen general practitioners conducted a multicentre double-blind clinical trial to compare oxamethacin (100 mg t.i.d.) with indomethacin (50 mg t.i.d.) for a maximum duration of 2 weeks. Each drug was administered to 339 patients suffering from various pathological conditions requiring a non-steroidal anti-inflammatory drug. When focusing on patients without associated drug therapy, 126/259 patients (50%) presented a good response on inflammation under oxamethacin and 98/236 patients (42%) a good response under indomethacin (p less than 10(-2)); 141/250 patients (56%) presented a good response on pain under oxamethacin and 117/236 (50%) under indomethacin (p less than 5.10(-2)). Side effects and complaints were reported by 34/250 patients (14%) under oxamethacin and by 67/236 (28%) under indomethacin (p less than 5.10(-5)). Some patients stopped treatment because of side-effects: 14/250 (6%) under oxamethacin and 32/236 (14%) under indomethacin (p less than 2.10(-3)).


Jan 1, 1979·The Journal of International Medical Research·J Polderman, M Colon

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