General Sources of Dopamine As a Potential Morphogenic Factor in the Developing Striatum of Rats

Doklady. Biochemistry and Biophysics
A I KurtovaMichael V Ugrumov

Abstract

In the striatum of rats at different stages of development, we determined the content of tyrosine hydroxylase and aromatic L-amino acids decarboxylase using double immunohistochemical labeling and estimated the expression level of their transcripts by real-time PCR. We found that, in different periods of development, there are three sources of dopamine in the striatum of rats: bienzymatic nerve fibers (throughout ontogeny), bienzymatic neurons (appear on day 18 of embryonic development), and monoenzymatic neurons (in adult animals). Dopamine, which is synthesized in the striatal neurons in the prenatal period, may function as a morphogenetic factor.

References

Sep 1, 1996·Neurochemical Research·M D BerryA A Boulton
Apr 18, 2002·Neuroscience·J AntonopoulosJ G Parnavelas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.