PMID: 6527235Dec 1, 1984Paper

General treatment of pH-solubility profiles of weak acids and bases and the effects of different acids on the solubility of a weak base

Journal of Pharmaceutical Sciences
W H StrengH G Tan

Abstract

The pH-solubility profile of a weak acid or base is shown to be a function of its pKsp, pKa, and uncharged species solubility. Equations are presented that can be used to calculate the solubility as a function of pH. These equations can also be used when there is added salt present. Experimental data was obtained in three cosolvent systems consisting of methanol-water and ethanol-water. Also, the effect of different acids on the solubility of a weak base is reported. A pronounced effect on the solubility by the addition of salt is explained in terms of the Ksp.

References

Sep 1, 1978·Journal of Pharmaceutical Sciences·Z T Chowhan

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Citations

Mar 21, 2007·Pharmaceutical Research·Maria VertzoniChristos Reppas
Apr 15, 2004·International Journal of Pharmaceutics·Stefan Balbach, Christian Korn
Sep 16, 1999·International Journal of Pharmaceutics·W H Streng
Mar 5, 2003·AIDS Patient Care and STDs·Sanjay GargLourens J D Zaneveld
Apr 24, 2008·AAPS PharmSciTech·Thorsteinn LoftssonPhatsawee Jansook
May 29, 2000·Drug Development and Industrial Pharmacy·H G ChoiC K Kim
Nov 9, 2001·Drug Development and Industrial Pharmacy·H G ChoiC K Kim
Sep 20, 2007·Journal of Pharmaceutical Sciences·Jeremy GuoJames N Herron
Mar 5, 2011·Journal of Pharmaceutical Sciences·Gregory A StephensonTimothy A Woods
Oct 25, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marijana ErcegChristos Reppas
Jul 15, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Raphael PausYuanhui Ji
Sep 1, 2015·Therapeutic Delivery·Jonas H Fagerberg, Christel As Bergström
Jun 13, 2012·The Journal of Pharmacy and Pharmacology·Christos Reppas, Maria Vertzoni
Jul 22, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Christel A S BergströmPer Artursson
Oct 24, 2006·Drug Discovery Today·Shobha N BhattacharJames A Wesley
May 31, 2016·Journal of Pharmaceutical Sciences·Stephen J FranklinPaul B Myrdal
Feb 7, 2013·Pharmacological Reviews·Hywel D WilliamsChristopher J H Porter
Mar 10, 2017·Drug Development and Industrial Pharmacy·Haichen NieQi Tony Zhou

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