PMID: 6527235Dec 1, 1984Paper

General treatment of pH-solubility profiles of weak acids and bases and the effects of different acids on the solubility of a weak base

Journal of Pharmaceutical Sciences
W H StrengH G Tan


The pH-solubility profile of a weak acid or base is shown to be a function of its pKsp, pKa, and uncharged species solubility. Equations are presented that can be used to calculate the solubility as a function of pH. These equations can also be used when there is added salt present. Experimental data was obtained in three cosolvent systems consisting of methanol-water and ethanol-water. Also, the effect of different acids on the solubility of a weak base is reported. A pronounced effect on the solubility by the addition of salt is explained in terms of the Ksp.


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