Generalization and differentiation in semantic memory: insights from semantic dementia.

Annals of the New York Academy of Sciences
Matthew A Lambon Ralph, Karalyn Patterson

Abstract

According to many theories, semantic representations reflect the parallel activation of information coded across a distributed set of modality-specific association brain cortices. This view is challenged by the neurodegenerative condition known as semantic dementia (SD), in which relatively circumscribed, bilateral atrophy of the anterior temporal lobes results in selective degradation of core semantic knowledge, affecting all types of concept, irrespective of the modality of testing. Research on SD suggests a major revision in our understanding of the neural basis of semantic memory. Specifically, it is proposed that the anterior temporal lobes form amodal semantic representations through the distillation of the multimodal information that is projected to this region from the modality-specific association cortices. Although cross-indexing of modality-specific information could be achieved by a web of direct connections between pairs of these regions, amodal semantic representations enable semantic generalization and inference on the basis of conceptual structure rather than modality-specific features. As expected from this hypothesis, SD is characterized by impaired semantic generalization, both clinically and in formal assess...Continue Reading

References

Jan 1, 1978·Neuropsychologia·A Wilkins, M Moscovitch
Nov 1, 1975·The Quarterly Journal of Experimental Psychology·E K Warrington
Dec 1, 1992·Brain : a Journal of Neurology·J R HodgesE Funnell
Sep 1, 1995·Memory·J S SnowdenD Neary
Jul 1, 1996·Brain and Cognition·D Neary, J Snowden
Jun 20, 2000·Cerebral Cortex·H GaravanE A Stein
Nov 30, 2002·Neuropsychologia·Sharon L Thompson-Schill
May 24, 2003·Brain : a Journal of Neurology·Alexander HammersJohn S Duncan
Feb 6, 2004·Psychological Review·Timothy T RogersKaralyn Patterson
May 26, 2005·Cognitive, Affective & Behavioral Neuroscience·Stephen R Welbourne, Matthew A Lambon Ralph
Nov 23, 2005·NeuroImage·Peter J NestorJohn R Hodges
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brian T GoldAnders H Andersen
Jul 4, 2006·Brain : a Journal of Neurology·Elizabeth Jefferies, Matthew A Lambon Ralph
Sep 14, 2006·Annual Review of Psychology·Alex Martin
Sep 19, 2006·Neurobiology of Aging·Béatrice DesgrangesFrancis Eustache
Sep 27, 2006·Ambulatory Pediatrics : the Official Journal of the Ambulatory Pediatric Association·Sheela SathyanarayanaCatherine Karr
Oct 31, 2006·Brain : a Journal of Neurology·A-L R AdlamJ R Hodges
Apr 3, 2007·NeuroImage·H W Robert PowellJohn S Duncan
Apr 3, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Karalyn Patterson
Apr 14, 2007·Nature Reviews. Neuroscience·Gregory Hickok, David Poeppel
Jun 23, 2007·Journal of Cognitive Neuroscience·Stephen R Welbourne, Matthew A Lambon Ralph
Nov 21, 2007·Nature Reviews. Neuroscience·Karalyn PattersonTimothy T Rogers
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gorana PobricMatthew A Lambon Ralph
Dec 29, 2007·Journal of the History of the Neurosciences·P J Koehler, F G I Jennekens
May 24, 2008·Neuropsychologia·Anna M WoollamsKaralyn Patterson

❮ Previous
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Citations

Mar 10, 2009·Journal of Neurology·Hugues DuffauEmmanuel Mandonnet
Jul 28, 2009·Journal of the International Neuropsychological Society : JINS·W Kyle Simmons, Alex Martin
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Matthew A Lambon RalphEmily J Mayberry
Jun 9, 2009·Neuropsychological Rehabilitation·Regina JokelNicole D Anderson
Jul 1, 2011·Neuropsychological Rehabilitation·Nathalie BierUNKNOWN SemAssist Team
Jan 19, 2012·Neuropsychological Rehabilitation·Regina Jokel, Nicole D Anderson
Aug 22, 2009·Brain : a Journal of Neurology·Jonathan A KnibbKaralyn Patterson
Nov 12, 2009·Brain : a Journal of Neurology·Jane E WarrenRichard J S Wise
Nov 28, 2009·Brain : a Journal of Neurology·Myrna F SchwartzH Branch Coslett
Oct 19, 2010·Brain : a Journal of Neurology·Matthew A Lambon RalphKaralyn Patterson
Sep 13, 2011·Brain : a Journal of Neurology·Julia C HailstoneJason D Warren
Aug 6, 2008·Cerebral Cortex·Matthew A Lambon RalphElizabeth Jefferies
Nov 4, 2011·Cerebral Cortex·Benno GesierichMaria Luisa Gorno-Tempini
Sep 23, 2010·Topics in Magnetic Resonance Imaging : TMRI·Roland Zahn
Dec 11, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Daniel Mirman, Allison E Britt
Dec 11, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Matthew A Lambon Ralph
Oct 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mohamed L Seghier, Cathy J Price
Apr 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert S HurleyM Marsel Mesulam
May 8, 2014·Behavioural Neurology·Guido Gainotti
Mar 13, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Guido Gainotti
Oct 16, 2014·Cerebral Cortex·Ellen F LauGina R Kuperberg
Apr 6, 2013·Cognitive, Affective & Behavioral Neuroscience·Nathaniel Delaney-Busch, Gina Kuperberg
Dec 29, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Sonya MehtaThomas Grabowski
Aug 3, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Guido Gainotti
Mar 25, 2011·Brain and Language·Cornelius WeillerMichel Rijntjes
Dec 17, 2010·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·David KemmererDaniel Tranel
May 25, 2010·Journal of Communication Disorders·Jamie ReillyJean Neils-Strunjas
Nov 19, 2008·Neuropsychologia·Hilary A C Green, Karalyn Patterson
Jan 1, 2009·Topics in Cognitive Science·Karalyn Patterson, David C Plaut
Feb 3, 2012·International Journal of Geriatric Psychiatry·M Verma, R J Howard
Apr 11, 2014·Scandinavian Journal of Psychology·Andrew Kertesz, Michał Harciarek
Mar 17, 2012·Brain Research·Cara Wong, Jason Gallate

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