PMID: 9545138Apr 17, 1998Paper

Generalized AA-amyloidosis in Siberian tigers (Panthera tigris altaica) with predominant renal medullary amyloid deposition

Veterinary Pathology
C SchulzeR P Linke

Abstract

Generalized amyloidosis with predominant renal medullary amyloid deposition was found in four closely related Siberian tigers (Panthera tigris altaica) suffering from end stage kidney diseases. Only minimal to mild amounts of amyloid were deposited in various organs outside the kidneys with individually variable organ involvement. The Congo red staining affinity of amyloid deposits was sensitive to potassium permanganate oxidation. The deposits were further characterized as being of the amyloid-A (AA) type by immunohistochemistry using the mouse monoclonal antibody mc4 directed against a conserved region of the human AA-protein. A combination of immunohistochemistry and Congo red staining was much more sensitive for the diagnosis of amyloid deposits than Congo red staining alone. With this combination, even minimal amyloid deposits were detected that had been missed in the first reading using Congo-red-stained slides alone. Since no common primary cause was identified, the amyloidosis was classified as idiopathic generalized AA-amyloidosis with a potential familial predisposition.

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Citations

Jul 19, 2008·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Sathya K ChinnaduraiRyan S DeVoe
Dec 31, 2008·Journal of Comparative Pathology·K M ColegroveL J Lowenstine
Sep 18, 2007·Acta Veterinaria Hungarica·Beáta Marianna KovácsP Rudas
May 12, 2012·Veterinary Medicine International·Moges Woldemeskel
Mar 12, 2003·Veterinary Pathology·C MénsuaL Luján
Sep 30, 2010·Veterinary Pathology·K M NewkirkE C Ramsay
Mar 27, 2020·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Eva Maria GreunzMads Frost Bertelsen
Oct 26, 2001·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·N A DezutterA M Verbruggen
Apr 20, 2005·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·J SegalésC Gortázar
Apr 18, 2021·Scientific Reports·Francesca GenovaMaria Longeri
Jun 17, 2021·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Hailey B PenticoffJessica S Fortin
Jun 17, 2021·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Stéphanie M MotaAmanda Guthrie

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