PMID: 3750736Jul 1, 1986Paper

Generalized amyloidosis in rhesus monkeys

Veterinary Pathology
J L BlanchardE A Watson

Abstract

Necropsy materials from 57 cases of generalized amyloidosis in rhesus monkeys were reviewed. Clinically, animals with the disease were characterized by cachexia with muscle wasting, recurrent diarrhea, and arthritis. Gross lesions included hepatomegaly, splenomegaly, chronic/active colitis, fibrous strictures of the cecocolic junction, osteoarthritis, and generalized muscle atrophy. Histologic examination revealed minimal to severe deposits of amyloid in the small intestine (100%), spleen (93%), large intestine (67%), liver (40%), lymph nodes (71%), stomach and/or adrenal gland (32%). More amyloid was deposited in the spleen, liver, and small intestine than in other organs. Shigella sp. were isolated from feces in 23% of the cases and 84% had histologic evidence of colitis. Other findings indicated that 100% of the animals had lung mites, 25% had strictures of the cecocolic junction, and 40% had osteoarthritis. Thirty percent of the cases occurred in animals 10 months to 5 years of age, 10% in ages 6 to 10 years, and 60% in animals greater than 10 years old.

References

Jan 1, 1979·Arthritis and Rheumatism·M D Benson, A S Cohen
Oct 1, 1978·The Journal of Experimental Medicine·G LavieE C Franklin
Mar 1, 1985·Scandinavian Journal of Immunology·A HusebekkG Marhaug
Jan 1, 1971·Veterinary Pathology·W G Sheldon, C A Gleiser
Oct 1, 1984·Cell Biology International Reports·T ShirahamaA S Cohen
Sep 1, 1982·Veterinary Pathology. Supplement·C A HolmbergJ Anderson
Jun 1, 1980·Arthritis and Rheumatism·A S Cohen, O Wegelius
Jan 1, 1982·Annals of the New York Academy of Sciences·E P BendittK A Walsh
Jun 12, 1980·Nature·M J SelingerD L Rosenstreich

❮ Previous
Next ❯

Citations

Jan 1, 1989·Pharmacology & Therapeutics·W Zschiesche, W Jakob
Mar 8, 2008·ILAR Journal·Murray B Gardner, Paul A Luciw
Jun 1, 1996·The Journal of Small Animal Practice·N J Mason, M J Day
Jan 1, 1989·Journal of Veterinary Internal Medicine·S P DiBartola, M D Benson
Jan 16, 2010·The Journal of Veterinary Medical Science·James Kenn ChambersYumi Une
Oct 30, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·David X LiuRonald S Veazey
Dec 31, 2008·Journal of Comparative Pathology·K M ColegroveL J Lowenstine
Apr 10, 2013·American Journal of Primatology·Kamm ProngayStephanie J Murphy
Dec 3, 2014·Virus Research·Patricia Aguilar-CalvoJuan María Torres
Feb 13, 2016·Veterinary Pathology·H A Simmons
Mar 9, 2005·Veterinary Pathology·E LudlageK G Mansfield
Jul 12, 2002·Journal of Medical Primatology·G B HubbardM M Leland
Jun 19, 2019·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Eric T LeungAmanda Vinson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.