Generalized basaloid follicular hamartoma syndrome versus Gorlin syndrome: A diagnostic challenge

Pediatric Dermatology
Alina ShevchenkoAmanda T Moon

Abstract

Basaloid follicular hamartoma is a relatively rare benign neoplasm of follicular origin that can be mistaken histologically for basal cell carcinoma, but hereditary forms of basaloid follicular hamartoma are associated with nevoid basal cell carcinoma syndrome, or Gorlin syndrome. The pathophysiology of basaloid follicular hamartoma development involves mutations in the patched gene, which is also causative in nevoid basal cell carcinoma syndrome. We present a mother and daughter with basaloid follicular hamartomas, with genetic testing confirming patched gene mutation in the daughter.

References

Jun 16, 2010·Annals of Dermatology·Jae Wan GoByung In Ro
Apr 5, 2014·The American Journal of Dermatopathology·Priyanka GumasteRonald Barr

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Citations

Jun 17, 2021·The American Journal of Dermatopathology·Ijeuru ChikekaViktoryia Kazlouskaya
Jul 2, 2021·Histopathology·Jaclyn M PlotzkePaul W Harms

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