Generalized benign cutaneous reaction to cytarabine

Journal of the American Academy of Dermatology
Beth S RubenLindy P Fox

Abstract

Cytarabine-induced toxicity manifests as various cutaneous morphologies. A generalized papular purpuric eruption has not been well described. We aimed to characterize a distinct cytarabine-related eruption. We reviewed all cases of cytarabine-related toxicity with papular purpuric eruptions or violaceous erythema at the University of California, San Francisco between 2006 and 2011. Sixteen cases were identified. The eruption began as erythematous papules that evolved into coalescing purpuric papules and plaques. It had affinity for intertriginous areas, neck, ears, and scalp. Pruritus was common, but no systemic complications were documented. Thirteen patients (81.3%) developed the eruption after completion of chemotherapy. Differential diagnosis often included viral exanthem (62.5%), drug eruption (50%), and vasculitis (37.5%). Histopathology was nonspecific but commonly demonstrated sparse lymphocytic infiltrates, spongiosis, and/or red cell extravasation. Importantly, the eruption was neither predicted by past cytarabine exposure nor predictive of future recurrence. This is a review of cases from a single institution. Observation was limited to acute hospitalization, however, charts were reviewed for subsequent reactions on ...Continue Reading

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Citations

Nov 28, 2018·International Journal of Dermatology·Rebecca F WangBenjamin H Kaffenberger
Oct 12, 2018·Revista brasileira de enfermagem·Tatiane Catleia Melo Dos Santos E SilvaRegina Célia Popim
Jan 23, 2021·Pediatric Dermatology·Shant TamazianJames R Treat
Sep 24, 2019·Case Reports in Dermatology·Pitchaya Jaruvijitrattana, Kumutnart Chanprapaph

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