PMID: 6409354Jun 13, 1983Paper

Generalized cerebral vasoconstriction induced by intracarotid infusion of angiotensin II in the rabbit

Brain Research
A M Reynier-RebuffelJ Seylaz

Abstract

This study investigated the influence of angiotensin II, perfused into one common carotid artery at a dose of 0.065 micrograms/kg/min, on the cerebrovascular resistance of the anesthetized rabbit by means of complementary in vivo methods. Heat clearance and mass spectrometry measurements indicated that in the homolateral caudate nucleus angiotensin induced a significant decrease in local blood flow (18.2 +/- 9%), a fall in pO2 (14.2 +/- 5.3%) and no significant change in pCO2. The [14C]ethanol tissue sampling technique revealed a significant decrease in flow in all 10 structures sampled in the brain. This decrease was similar in magnitude in both the ipsilateral and the contralateral hemisphere with regard to the site of injection. When expressed in terms of cerebrovascular resistance (CVR) and allowing for a slight increase in blood pressure (less than 10%), these results show that angiotensin II infusion induced an increase in CVR of 18-32%. We conclude that: A unilateral intracarotid infusion of a low dose of angiotensin II induces an increased vascular tone in all cerebral structures. This action, being bilateral, cannot readily be explained by a direct action of angiotensin II on the cerebral vessels in view of the very lo...Continue Reading

References

Aug 1, 1978·Journal of Comparative and Physiological Psychology·J B SimpsonJ S Camardo
Apr 1, 1975·Endocrinology·L C KeilW B Severs
Feb 15, 1975·Klinische Wochenschrift·E UhlichU Gröschel-Stewart
Sep 1, 1979·Medical & Biological Engineering & Computing·P LacombeJ Seylaz
Mar 1, 1979·Acta Physiologica Scandinavica·L EdvinssonC Owman
Nov 1, 1979·Stroke; a Journal of Cerebral Circulation·N A LusamvukuJ Seylaz
Apr 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J Seylaz, E Pinard
Sep 1, 1978·Stroke; a Journal of Cerebral Circulation·E P WeiJ L Patterson
Jan 1, 1976·Acta Physiologica Scandinavica·A Bill, J Linder
Dec 18, 1965·Lancet·R Yu, C J Dickinson
Aug 1, 1970·Clinical Science·C M FerrarioJ W McCubbin
Feb 1, 1971·British Journal of Pharmacology·J Hughes, R H Roth
Mar 1, 1972·Circulation Research·C M FerrarioJ W McCubbin
Apr 1, 1973·Clinical Science·P L GildenbergJ W McCubbin
Dec 1, 1974·Journal of Applied Physiology·J SeylazH Mamo
Jan 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O U ScreminE H Rubinstein
Feb 1, 1981·Brain Research Bulletin·S Ishibashi, S Nicolaidis

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Citations

Jan 1, 1994·Neuroscience and Biobehavioral Reviews·J W Wright, J W Harding
Dec 20, 2002·Journal of Neurotrauma·Dimitry Baranov, William M Armstead
Mar 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K TamakiJ Ogata
Oct 1, 1995·Stroke; a Journal of Cerebral Circulation·M A MaktabiG Stachovic

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