PMID: 8340502Aug 1, 1993Paper

Generalized eruptive keratoacanthoma of Grzybowski

Journal of the American Academy of Dermatology
P W JaberK E Greer


A patient with generalized eruptive keratoacanthoma of Grzybowski is described. Our findings, along with those of the 21 reported cases from the world literature, are summarized. This rare variant of keratoacanthoma most commonly affects patients in the fifth to seventh decades of life and appears as a generalized eruption of hundreds to thousands of follicular papules. These small papules often have a keratotic center and demonstrate the microscopic features of keratoacanthoma. Marked facial involvement is characteristic and can lead to masked facies with ectropion. Severe pruritus, mucosal lesions, and koebnerization are features of the disease. The course is chronic and the response to therapy is poor, although a few patients have improved with the use of systemic retinoids.


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May 3, 2000·The British Journal of Dermatology·J E ConsigliS Maldonado
Jul 18, 2014·Dermatologic Therapy·N BruscinoG M Palleschi
Jul 30, 2014·International Journal of Dermatology·Ahmad NofalAyman Yosef
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Aug 8, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·A NofalM Alradi
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May 1, 1995·The Australasian Journal of Dermatology·G M KavanaghM M Hanna
Apr 22, 2005·The Australasian Journal of Dermatology·Amanda Oakley, Stephen Ng
Aug 1, 1997·The Journal of Dermatology·A SingalN Singh

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