Generalized Laminar Population Analysis (gLPA) for Interpretation of Multielectrode Data from Cortex

Frontiers in Neuroinformatics
Helena T GłąbskaDaniel K Wójcik

Abstract

Laminar population analysis (LPA) is a method for analysis of electrical data recorded by linear multielectrodes passing through all lamina of cortex. Like principal components analysis (PCA) and independent components analysis (ICA), LPA offers a way to decompose the data into contributions from separate cortical populations. However, instead of using purely mathematical assumptions in the decomposition, LPA is based on physiological constraints, i.e., that the observed LFP (low-frequency part of signal) is driven by action-potential firing as observed in the MUA (multi-unit activity; high-frequency part of the signal). In the presently developed generalized laminar population analysis (gLPA) the set of basis functions accounting for the LFP data is extended compared to the original LPA, thus allowing for a better fit of the model to experimental data. This enhances the risk for overfitting, however, and we therefore tested various versions of gLPA on virtual LFP data in which we knew the ground truth. These synthetic data were generated by biophysical forward-modeling of electrical signals from network activity in the comprehensive, and well-known, thalamocortical network model developed by Traub and coworkers. The results fo...Continue Reading

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Citations

Mar 11, 2020·PLoS Computational Biology·Jan-Eirik W SkaarGaute T Einevoll
Jan 9, 2019·Frontiers in Neuroinformatics·Espen HagenGaute T Einevoll
Nov 12, 2016·Neuroinformatics·Helena GłąbskaDaniel K Wójcik

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Software Mentioned

MATLAB
gLPA
Python
NEURON

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