Generalized Multinucleate Cell Angiohistiocytoma

Journal of Cutaneous Medicine and Surgery
Jennifer A E DoaneSylvia Pasternak

Abstract

There are less than 100 cases of multinucleate cell angiohistiocytoma (MCA) currently reported in the literature. It occurs as a localized, asymptomatic, benign proliferation of the skin, characterized histologically by irregular multinucleate cells. Due to its novelty, the etiology of the disease and treatment options are still under investigation. To report a case of confirmed, generalized MCA along with a review of the literature on the histology, immunology, potential etiology, and treatment of MCA. The patient was a 41-year-old female with asymptomatic violaceous plaques found on the extensor arms, legs, and trunk. Histopathology revealed increased dilated vascularity and cellularity (composed of mononuclear histiocytes and a few angulated multinucleated giant cells) in the dermis. Overall, MCA is a poorly understood, distinct dermatologic phenomenon. Here we present a case of generalized MCA to further the understanding of this disease presentation.

References

Apr 28, 2006·Journal of Cutaneous Pathology·Lidia Pérez PérezJaime Toribio
May 15, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Beatriz Fernández-JorgeEduardo Fonseca
Jul 21, 2010·The American Journal of Dermatopathology·Anna Maria CesinaroAntonio Maiorana
Feb 15, 2011·Actas dermo-sifiliográficas·P Valerón-AlmazánG Carretero

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