PMID: 1179330Aug 1, 1975Paper

Generalized pulmonary hyperinflation and Fallot's tetralogy in a neonate investigated by pulmonary physiological and radioisotopic methods

S GodfreyK A Hallidie-Smith


An infant is described who presented a complex cardiopulmonary problem which was evaluated with the help of new physiological techniques. the infant was born at term after an emergency Caesarian section for fetal distress and was found to have meconium aspiration. He remained persistently tachypnoeic and hypoxic despite high ambient oxygen. Chest radiography suggested cystic lesions at the lung bases, and lung function tests confirmed hyperinflation with delayed nitrogen washout. In addition the child had signs of Fallot's tetralogy, and this diagnosis was confirmed by cardiac catheterization. Because of persistent hypoxia and tachypnoea disproportionate to the cardiac condition, the possibility of localized lung disease was considered. Regional lung function tests were carried out in the neonatal period and again at six months of age useing radioisotopic 13N given by both inhalation and injection. These studies showed gross ventilation/perfusion imbalance in the lungs, particularly marked at the bases, but with enough generalized abnormality to preclude the possibility of surgical intervention. The principles of the measurement of lung mechanics in the newborn by whole-body plethysmography, nitrogen washout, and regional radio...Continue Reading


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Oct 1, 1972·Archives of Disease in Childhood·G Howlett
Sep 1, 1969·Pediatric Research·P D Phelan, H E Williams
Nov 1, 1969·American Journal of Diseases of Children·G B Merenstein
Aug 1, 1970·The Journal of Pediatrics·A N Krauss, P A Auld
Jan 1, 1971·Annals of Surgery·J C LincolnD J Waterston
Nov 1, 1966·The Journal of Pediatrics·G Polgar, S T String
Mar 1, 1957·The Journal of Clinical Investigation·C D COOKC A SMITH
Dec 1, 1963·The Journal of Clinical Investigation·N M NELSONC A SMITH
Mar 10, 1962·Nature·K KRISCH
Jan 6, 1962·Nature·E NELSON
Sep 1, 1949·The Journal of Physiology·K W CROSS

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Sep 1, 1976·Archives of Disease in Childhood
Nov 1, 1977·Archives of Disease in Childhood·S Godfrey, S McKenzie
Jan 1, 1977·British Journal of Diseases of the Chest·S GodfreyN Freedman
Aug 1, 1975·Archives of Disease in Childhood·R RonchettiS Godfrey

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