PMID: 9552755Apr 29, 1998Paper

Generalized pustular drug eruptions: confirmation by in vitro tests

Journal of the European Academy of Dermatology and Venereology : JEADV
A LazarovSima Halevy

Abstract

Generalized pustular eruptions are characterized by acute onset of aseptic pustules in febrile patients with leukocytosis after exposure to the offending drug. They have been regarded as uncommon manifestations of adverse drug reactions. Until now few confirmation studies have been carried out. Our purpose was to describe a series of patients with generalized pustular drug eruption. The diagnosis and etiological role of drugs in these cases was confirmed by two in vitro tests, namely the macrophage migration inhibitory factor (MIF) and the mast cell degranulation (MCD) tests. The clinical, pathological and laboratory findings in six patients with generalized pustular eruption were studied prospectively. The MIF and MCD tests were performed with the drugs taken by the patients. The dermatological manifestations included numerous pustules on large erythematous areas, papules and erythema multiforme-like lesions. The pustular eruption developed between 12 h and 5 days after the administration of the provoking drug. The histopathological changes were characterized by subcorneal pustules, papillary edema and mixed cell inflammatory infiltrate. In two biopsies the infiltrate displayed numerous eosinophils. Laboratory investigations r...Continue Reading

Citations

Oct 27, 2001·International Journal of Dermatology·A D CohenS Halevy
May 27, 1999·Journal of the European Academy of Dermatology and Venereology : JEADV·E Koumantaki-MathioudakiA Katsambas
Feb 13, 2001·Journal of Cutaneous Pathology·A SidoroffJ C Roujeau
Aug 19, 2009·Annales de dermatologie et de vénéréologie·A Barbaud

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