Generalized Recurrent Neural Network accommodating Dynamic Causal Modeling for functional MRI analysis

NeuroImage
Yuan WangYvonne W Lui

Abstract

Dynamic Causal Modeling (DCM) is an advanced biophysical model which explicitly describes the entire process from experimental stimuli to functional magnetic resonance imaging (fMRI) signals via neural activity and cerebral hemodynamics. To conduct a DCM study, one needs to represent the experimental stimuli as a compact vector-valued function of time, which is hard in complex tasks such as book reading and natural movie watching. Deep learning provides the state-of-the-art signal representation solution, encoding complex signals into compact dense vectors while preserving the essence of the original signals. There is growing interest in using Recurrent Neural Networks (RNNs), a major family of deep learning techniques, in fMRI modeling. However, the generic RNNs used in existing studies work as black boxes, making the interpretation of results in a neuroscience context difficult and obscure. In this paper, we propose a new biophysically interpretable RNN built on DCM, DCM-RNN. We generalize the vanilla RNN and show that DCM can be cast faithfully as a special form of the generalized RNN. DCM-RNN uses back propagation for parameter estimation. We believe DCM-RNN is a promising tool for neuroscience. It can fit seamlessly into c...Continue Reading

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