PMID: 3771860Nov 1, 1986Paper

Generalized trichoepitheliomas with alopecia and myasthenia gravis: clinicopathologic and immunohistochemical study and comparison with classic and desmoplastic trichoepithelioma

Journal of the American Academy of Dermatology
T M StarinkC J Meijer

Abstract

We report on a patient with a syndrome characterized by smooth facial papules and nodules; alopecia of the eyebrows, eyelashes, and most body hair; mild alopecia of scalp hair; possibly hypohidrosis; and myasthenia gravis. The clinical, histologic, and immunohistochemical findings are compared with classic and desmoplastic trichoepitheliomas. All fourteen biopsy specimens of the patient showed a lacelike network of basaloid cells with follicular differentiation and a prominent stroma with focal alkaline phosphatase activity, as in fourteen comparison specimens of classic trichoepithelioma. Studies with antikeratin antibodies of various specificities also revealed similar patterns. The tumor cells showed a keratin phenotype characteristic of cells of the infrainfundibular outer root sheath, that is, positive staining with basal keratinocyte markers, negative staining with suprabasal keratinocyte markers, and patchy staining with LP2K (against keratin 19). beta 2-Microglobulin expression was partially or totally absent. It is concluded that the lesions in our patient actually are trichoepitheliomas. The condition may represent a new syndrome that either is closely related to the generalized hair follicle hamartoma (basaloid folli...Continue Reading

References

Jan 1, 1985·Annals of the New York Academy of Sciences·E B LaneI M Leigh

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Citations

Aug 1, 1995·Journal of the American Academy of Dermatology·A L GerretsenW A van Vloten
Nov 26, 2003·Journal of the American Academy of Dermatology·Kathleen J Smith, Henry Skelton
Nov 9, 2000·The British Journal of Dermatology·H ShimizuM Ueda
Oct 20, 2004·The Journal of Dermatology·Kenta TsuruMasato Ueda
Apr 25, 2000·The Journal of Dermatology·S A CenturiónW C Lambert
Oct 1, 1992·The Journal of Dermatology·N KatoJ Nakamura
Aug 1, 1993·Journal of Cutaneous Pathology·E Alessi, A Azzolini
Feb 1, 1992·The British Journal of Dermatology·A C MarkeyI M Leigh
Nov 1, 1991·The British Journal of Dermatology·S C MayouD J Lowe
May 5, 2005·International Journal of Dermatology·Mohammad A El-DaroutiMarwa M Fawzy
Jan 30, 2019·Annales de dermatologie et de vénéréologie·G HazemannB Cribier
Jul 31, 2010·Archives of Pathology & Laboratory Medicine·Omie Mills, L Brannon Thomas

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