Generalized verrucosis in a patient with GATA2 deficiency

The British Journal of Dermatology
E S WestM E Grossman

Abstract

Generalized verrucosis is a characteristic of several genetic and immunodeficiency disorders including epidermodysplasia verruciformis; warts, hypogammaglobulinaemia, infections and myelokathexis (WHIM) syndrome; warts, immunodeficiency, lymphoedema and anogenital dysplasia (WILD) syndrome; severe combined immune deficiency and HIV, among others. In recent years, it has been consistently recognized in patients with GATA2 deficiency, a novel immunodeficiency syndrome characterized by monocytopenia, B-cell and natural killer-cell lymphopenia, and a tendency to develop myeloid leukaemias and disseminated mycobacterial, human papillomavirus (HPV) and opportunistic fungal infections. Mutations in GATA2 cause haploinsufficiency and track in families as an autosomal dominant immunodeficiency. GATA2 is a transcription factor involved in early haematopoietic differentiation and lymphatic and vascular development. We describe a case of generalized verrucosis with HPV type 57 presenting in a young man with GATA2 deficiency. GATA2 deficiency is a novel dominant immunodeficiency that is often recognized later in life and should be considered in the differential diagnosis of patients with generalized verrucosis.

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Citations

Aug 19, 2015·Journal of the American Academy of Dermatology·Dominique C PichardEdward W Cowen
Feb 25, 2015·British Journal of Haematology·Matthew CollinVenetia Bigley
May 9, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·A M Delgado-MárquezF Vanaclocha
Apr 5, 2017·The Journal of Allergy and Clinical Immunology. in Practice·Joshua M DornRoshini S Abraham
Apr 26, 2017·The British Journal of Dermatology·A PolatA Dupuy
Nov 28, 2017·The Journal of Dermatology·Yuko KuriyamaAkira Shimizu
Jul 17, 2019·American Journal of Clinical Pathology·Olga K WeinbergKatherine R Calvo
Jan 5, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hideyuki KosumiHiroshi Shimizu
Jul 11, 2018·Frontiers in Immunology·Cristiane de Jesus Nunes-Santos, Sergio D Rosenzweig
Dec 21, 2020·Anais Brasileiros De Dermatologia·Geraldo Magela MagalhãesMarcelo Grossi Araújo
May 10, 2021·Transplantation and Cellular Therapy·Mark PartaDennis D Hickstein

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