Generalized vitiligo after lymphocyte infusion for relapsed leukaemia

The British Journal of Dermatology
W Y AuA K Lie

Abstract

Vitiligo is an autoimmune disease caused by T-lymphocyte-mediated destruction of melanocytes. We describe two patients with generalized vitiligo caused iatrogenically after donor lymphocyte infusion (DLI) for leukaemia relapse over 3 years after bone marrow transplantation (BMT). Neither the sibling donor nor the recipient had vitiligo or other autoimmune diseases, and vitiligo did not occur after the first BMT. DLI was accompanied by skin graft-versus-host disease in both cases, which was controlled with immunosuppression. However, over several months, progressive generalized and persistent skin depigmentation occurred in both patients. Peripheral blood molecular studies showed the complete disappearance of host haematolymphopoiesis. The specific destruction of melanocytes in both patients was therefore probably mediated by new alloreactive lymphocytes infused from the donors.

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Citations

Jul 5, 2007·Journal of Pediatric Hematology/oncology·Shelley Cathcart, Dean Morrell
Feb 21, 2008·Dermatology : International Journal for Clinical and Investigative Dermatology·Hatice SanliOsman Ilhan
Mar 17, 2012·Journal of the American Academy of Dermatology·Sharon R HymesEdward W Cowen
Nov 7, 2006·Pigment Cell Research·Francisco SolanoGhanem Ghanem
Nov 27, 2008·Pediatric Transplantation·Fethi MellouliMohamed Béjaoui
Mar 21, 2006·Journal of the American Academy of Dermatology·Chih-Chieh ChanTsen-Fang Tsai
Apr 21, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Zhuoyan LiBipin N Savani
Mar 26, 2003·Histopathology·M R Canninga-van DijkJ G van den Tweel
Mar 8, 2003·Pigment Cell Research·Katia OngenaeJean-Marie Naeyaert
Jul 31, 2019·Bone Marrow Transplantation·Alessio TotaniIan Lewis

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